Molecular Therapy: Nucleic Acids, 2017 Triple negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer. It is associated with a very poor prognosis and intrinsically resistant to several conventional and targeted chemotherapy agents and has a 5-year survival ...
Behrad Darvishi +2 more
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The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
Journal of Nanobiotechnology, 2022 Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays a crucial role in the subsequent treatments ...
Hossein Kamali +5 more
doaj +1 more source
HIV-1 Gag Specific IgG Response in Mice Immunized with Vp22-Gag Vaccine Candidate [PDF]
, 2017 Background : Stimulation of Gag-specific CD8+ T-cell response, associated with reduction in viremia, viral replication control, and slow disease progression. Effective CD8+ T cell response is also influenced by CD4+ T cells.
Bekti, H. S. (Heri)
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Lipid-free Antigen B subunits from echinococcus granulosus: oligomerization, ligand binding, and membrane interaction properties [PDF]
, 2015 Background: The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host.
Córsico, Betina +5 more
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Tumor Biology, 2017 Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival rate of patients have made triple-negative breast cancer to be considered as the most lethal ...
Behrad Darvishi +3 more
doaj +1 more source
Homemade plasmid Miniprep solutions for affordable research in low-fund laboratories
AMB Express, 2022 As a consequence of Covid-19 pandemic, the basic lab consumables are in shortage, especially in the low-income countries. Thus, the main objective of the present study is to develop and evaluate homemade solution to isolate plasmid.
Mohamed A. Elnagar +6 more
doaj +1 more source
Recombination of Fragmented Proteins [PDF]
Chemistry & Biology, 2004 Directed evolution is a powerful method for generating novel molecules with desirable properties. In developing a new sensor to screen for protein-protein interactions, Tafelmeyer et al. report a clever strategy to evolve heterodimeric "split proteins" from a monomer in this issue of Chemistry & Biology.
openaire +2 more sources
Recombinant Protein Stability in Cyanobacteria [PDF]
ACS Synthetic Biology, 2021 The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize and efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier to the overexpression of recombinant proteins in most expression systems. A notable exception is the overexpression in E.
Xianan Zhang +3 more
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Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]
, 1993 A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Amman +29 more
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C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]
, 2015 Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca +9 more
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