Results 31 to 40 of about 2,626,165 (307)

NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer

Tumor Biology, 2017
Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival rate of patients have made triple-negative breast cancer to be considered as the most lethal ...
Behrad Darvishi, Leila Farahmand, Zahra Eslami-S, Keivan Majidzadeh-A   +3 more
doaj   +1 more source

Homemade plasmid Miniprep solutions for affordable research in low-fund laboratories

AMB Express, 2022
As a consequence of Covid-19 pandemic, the basic lab consumables are in shortage, especially in the low-income countries. Thus, the main objective of the present study is to develop and evaluate homemade solution to isolate plasmid.
Mohamed A. Elnagar, Mohamed F. Ibrahim, Magdy Albert, Maya M.Talal, Mahmoud M. Abdelfattah, Ehab El-Dabaa, Reham Helwa   +6 more
doaj   +1 more source

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines [PDF]

, 2012
Monoclonal antibodies are commercially important, high value biotherapeutic drugs used in the treatment of a variety of diseases. These complex molecules consist of two heavy chain and two light chain polypeptides covalently linked by disulphide bonds ...
Martin, Elaine B., C Mark Smales, Sarah K. Spurgeon (128819), Mead, Emma J., Emma J. Mead (128810), Smales, C. Mark, Chiverton, Lesley M., Smales, Christopher Mark, Elaine B. Martin (128823), C. Mark Smales (128831), Spurgeon Sarah K., Spurgeon, Sarah K., Montague, Gary A.; id_orcid, Montague, Gary A, Smales C. Mark, Montague, Gary A., von der Haar Tobias, Smales, C Mark, Emma J Mead, Sarah K Spurgeon, Gary A Montague, Martin Elaine B., Gary A. Montague (128826), von der Haar, Tobias, Mead, Emma J, Lesley M. Chiverton (128814), Chiverton Lesley M., Elaine B Martin, Tobias von der Haar, Tobias von der Haar (80575), Mead Emma J., Montague Gary A., Lesley M Chiverton   +32 more
core   +2 more sources

Porcine antibody profiles of 33 Mycoplasma hyopneumoniae fusion proteins from M. hyopneumoniae natural infection but not vaccination

Veterinary Medicine and Science, 2023
Background Mycoplasma hyopneumoniae, the primary pathogen responsible for porcine enzootic pneumonia, reduces average daily weight gain and causes substantial economic losses to the pig industry worldwide.
Yaru Ning, Yujiao Yang, Yaqin Tian, Yun Zhang, Wenyi Luo, Yukang Wen, Yaoqin Zhou, Honglei Ding   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies

Cancer Cell International
Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer has been noted. On the other hand, the binding
Mohadeseh Haji Abdolvahab, Pegah Karimi, Nasrin Mohajeri, Mohammad Abedini, Hamed Zare   +4 more
doaj   +1 more source

Fusing the 3’UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds

Scientific Reports, 2023
The demand for recombinant proteins is rising dramatically, and effective production systems are currently being developed. The production of recombinant proteins in plants is a promising approach due to its low cost and low risk of contamination of the ...
Masatake Kanai, Masaya Sugiyama, Maki Kondo, Kenji Yamada, Mikio Nishimura, Shoji Mano   +5 more
doaj   +1 more source

New Frontiers in the Production of Functional Recombinant Proteins. [PDF]

Bioengineering (Basel)
Recombinant protein technology, a pivotal subset of biotechnology, facilitates the generation of specific proteins via recombinant DNA techniques, predominantly within heterologous expression systems [...
Luo X, Ma Y, Xiang Q.
europepmc   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source