Results 51 to 60 of about 2,626,165 (307)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Purification and biochemical characterization of recombinant proteins.

, 2016
(A) Coomassie-stained SDS-PAGE of purified recombinant proteins. Proteins LFn-NADase, LFn-190NADase, NADase, and 190NADase were released from IFS and purified using a novel protocol in which the proteins were denatured, purified, and then refolded ...
Onkar Sharma (2552671), Michael R. Wessels (53623), Maghnus O’Seaghdha (2552668), Jorge J. Velarde (2552674)   +3 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Recombinant expression of fungal oxidases for industrial application [PDF]

, 2005
Laccases catalyse the oxidation of a range of organic substrates coupled to the reduction of molecular oxygen to water. They are members of the ubiquitous blue multi-copper oxidase family.
Piscitelli, Alessandra
core   +1 more source

Three Parts of the Plant Genome: On the Way to Success in the Production of Recombinant Proteins

Plants, 2022
Recombinant proteins are the most important product of current industrial biotechnology. They are indispensable in medicine (for diagnostics and treatment), food and chemical industries, and research.
Sergey M. Rozov, Alla A. Zagorskaya, Yuri M. Konstantinov, Elena V. Deineko   +3 more
doaj   +1 more source

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. [PDF]

, 2015
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Kerber, Sarah, Zimmer, Gert, Miriam Bolz, Sarah Kerber (421868), Bolz, Miriam, Gerd Pluschke, Miriam Bolz (309717), Gert Zimmer, Sarah Kerber, Gerd Pluschke (7855), Pluschke, Gerd, Gert Zimmer (223023), Kerber S, Bolz Miriam, Pluschke G, Zimmer G, Kerber Sarah, Pluschke Gerd, Bolz M, Zimmer Gert   +19 more
core   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Synergistic combination of pirfenidone and paclitaxel suppresses migration and stemness in triple-negative breast cancer: implications of EMT and pluripotency pathways

BMC Pharmacology and Toxicology
Triple-negative breast cancer (TNBC) is an aggressive type of cancer with limited treatment options and high risks of metastasis and recurrence. Growing evidence shows that paclitaxel (PTX), a first-line chemotherapeutic agent in TNBC, may paradoxically ...
Nima Rastegar-Pouyani, Hamed Zare, Farnaz Rezaei, Sahar Khazen, Mohadeseh Haji Abdolvahab   +4 more
doaj   +1 more source

Improved methods for production and characterisation of Jembrana disease virus proteins [PDF]

, 2010
Jembrana disease is an acute disease of Bali cattle (Bos javanicus) in Indonesia caused by Jembrana disease virus (JDV), a lentivirus most closely related to Bovine immunodeficiency virus. Control of the disease in Bali cattle, which are important to the
Rachmat, Judhi
core