Results 71 to 80 of about 2,626,165 (307)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

New insights into Chitosan nano-carriers for RNA delivery and carbon dot imaging for cancer theranostics: challenges and future prospects

Cancer Nanotechnology
Cancer therapy and imaging remain multifaceted global health challenges for patients, investigators, and medical practitioners. RNA-based therapies, facilitated by nanotechnology, show great potential for targeted treatment due to their high specificity ...
Mohammad Jafar Mantashlou, Javad Sarvmeili, Nasrin Mohajeri, Fatemeh Hampaei, Sevil Vaghefi Moghaddam, Effat Alizadeh   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

GRP-based vaccines as a novel approach in cancer immunotherapy: mechanisms, challenges, and prospects

Cancer Cell International
Glucose-regulated proteins (GRPs), key members of the heat shock protein (HSP) family, function as molecular chaperones that are upregulated under endoplasmic reticulum (ER) stress. Prominent GRPs such as GRP78, GRP94/gp96, GRP75, and GRP170 play a great
Razieh Malekian Shahreza, Hamed Zare, Nima Rastegar-Pouyani, Hamid Aria, Fatemeh Hakim, Mohammad Arefnia, Hamid Bakherad   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Recombinant proteins used in the study.

, 2022
Details for the recombinant proteins used in the multiplex immunoassays used in the study. (DOCX)
Marcelo U. Ferreira (7180982), Chunxiang Wu (14165192), Julian C. Rayner (7373144), Josué C. Lima-Junior (14165204), Quyen Q. Hoang (1820989), Ivo Mueller (46609), Rhea J. Longley (9732602), Roberta Reis Soares (14165198), Kézia KG Scopel (14165201), Tenzin Tashi (14165189), Tuan M. Tran (254595), Wai-Hong Tham (136834), Aditi Upadhye (10165541), Prasun Kundu (11061038), Sébastien Menant (14165195)   +14 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A monoclonal antibody collection for C. difficile typing ?

Gut Pathogens
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most
Lise Hunault, Patrick England, Frédéric Barbut, Bruno Iannascoli, Ophélie Godon, François Déjardin, Christophe Thomas, Bruno Dupuy, Chunguang Guo, Lynn Macdonald, Guy Gorochov, Delphine Sterlin, Pierre Bruhns   +12 more
doaj   +1 more source

Precision Fermentation as an Alternative to Animal Protein, a Review

Fermentation
The global food production system faces several challenges, including significant environmental impacts due to traditional agricultural practices. The rising demands of consumers for food products that are safe, healthy, and have animal welfare standards
Marilia M. Knychala, Larissa A. Boing, Jaciane L. Ienczak, Débora Trichez, Boris U. Stambuk   +4 more
doaj   +1 more source

Chromatographic Analysis of Recombinant Lysostaphin Expressed in Escherichia coli [PDF]

, 2011
Lysostaphin (EC.3.4.24.75) is an extracellular glycylglycine endopeptidase produced exclusively by Staphylococcus simulans biovar staphylolyticus (ATCC 1362, NRRL B-2628).
Jennings, Claire
core