Results 21 to 30 of about 742,504 (289)

NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer

open access: yesTumor Biology, 2017
Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival rate of patients have made triple-negative breast cancer to be considered as the most lethal ...
Behrad Darvishi   +3 more
doaj   +1 more source

Homemade plasmid Miniprep solutions for affordable research in low-fund laboratories

open access: yesAMB Express, 2022
As a consequence of Covid-19 pandemic, the basic lab consumables are in shortage, especially in the low-income countries. Thus, the main objective of the present study is to develop and evaluate homemade solution to isolate plasmid.
Mohamed A. Elnagar   +6 more
doaj   +1 more source

Recombination of Fragmented Proteins [PDF]

open access: yesChemistry & Biology, 2004
Directed evolution is a powerful method for generating novel molecules with desirable properties. In developing a new sensor to screen for protein-protein interactions, Tafelmeyer et al. report a clever strategy to evolve heterodimeric "split proteins" from a monomer in this issue of Chemistry & Biology.
openaire   +2 more sources

Recombinant Protein Stability in Cyanobacteria [PDF]

open access: yesACS Synthetic Biology, 2021
The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize and efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier to the overexpression of recombinant proteins in most expression systems. A notable exception is the overexpression in E.
Xianan Zhang   +3 more
openaire   +5 more sources

Porcine antibody profiles of 33 Mycoplasma hyopneumoniae fusion proteins from M. hyopneumoniae natural infection but not vaccination

open access: yesVeterinary Medicine and Science, 2023
Background Mycoplasma hyopneumoniae, the primary pathogen responsible for porcine enzootic pneumonia, reduces average daily weight gain and causes substantial economic losses to the pig industry worldwide.
Yaru Ning   +7 more
doaj   +1 more source

Identification of Breast Cancer Associated Putative Functional Single Nucleotide Polymorphisms in the Iranian Population through In Silico Analyses [PDF]

open access: yesJournal of Cell and Molecular Research, 2020
Previous studies have found several distinct alleles at both levels of transcriptional activity and protein-DNA binding manners in breast cancer patients vs. healthy individuals through multi-step experimental approaches.
Vida Nadafi Sichani   +4 more
doaj   +1 more source

Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2019
Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective.
Mohammad Doosti   +4 more
doaj   +1 more source

Fusing the 3’UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds

open access: yesScientific Reports, 2023
The demand for recombinant proteins is rising dramatically, and effective production systems are currently being developed. The production of recombinant proteins in plants is a promising approach due to its low cost and low risk of contamination of the ...
Masatake Kanai   +5 more
doaj   +1 more source

Flexible approaches are required for successful production of recombinant proteins in plants

open access: yesMedicine Science, 2022
Production of recombinant proteins has increased significantly due to the ever-increasing demand in research laboratories, medical fields, and agriculture.
Nilufer Gun, Tarlan Mamedov
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

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