Results 91 to 100 of about 5,115,827 (299)

Recombinant gelatin and collagen from methylotrophic yeasts [PDF]

, 2002
Based on its structural role and compatibility within the human body, collagen is a commonly used biomaterial in medical applications, such as cosmetic surgery, wound treatment and tissue engineering.
Bruin, E.C., de
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A novel anti-CD22 scFv–apoptin fusion protein induces apoptosis in malignant B-cells

AMB Express, 2017
CD22 marker is a highly internalizing antigen which is located on the surface of B-cells and is being used as a promising target for treatment of B cell malignancies.
Solmaz Agha Amiri, Soraya Shahhosseini, Najmeh Zarei, Dorsa Khorasanizadeh, Elahe Aminollahi, Faegheh Rezaie, Mehryar Zargari, Mohammad Azizi, Vahid Khalaj   +8 more
doaj   +1 more source

Advanced analytical strategies for recombinant therapeutic proteins.

Current pharmaceutical biotechnology, 2011
Therapeutic proteins produced using recombinant DNA technologies are generally complex, heterogeneous, and subject to a variety of enzymatic or chemical modifications during expression, purification, and long-term storage. Hence the analytical strategies for characterization, quantitation, purity assay and evaluation of the biological activity of ...
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Improved methods for production and characterisation of Jembrana disease virus proteins [PDF]

, 2010
Jembrana disease is an acute disease of Bali cattle (Bos javanicus) in Indonesia caused by Jembrana disease virus (JDV), a lentivirus most closely related to Bovine immunodeficiency virus. Control of the disease in Bali cattle, which are important to the
Rachmat, Judhi
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Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products

Journal of Biological Engineering
Protein-based therapeutics have garnered increasing attention across various medical fields for their substantial benefits to human health. Existing strategies for intracellular protein delivery, such as cell-penetrating peptide (CPP)-based approaches ...
Giorgio Medici, Giulia Candini, Nicola Mottolese, Beatrice Uguagliati, Federica Trebbi, Manuela Loi, Angelica Marina Bove, Spase Stojanov, Erika Esposito, Rosalba Vitagliano, Federica D’Amico, Silvia Turroni, Jessica Fiori, Aleš Berlec, Stefania Trazzi, Elisabetta Ciani   +15 more
doaj   +1 more source

Accumulation and processing of a recombinant protein designed as a cleavable fusion to the endogenous Rubisco LSU protein in Chlamydomonas chloroplast

BMC Biotechnology, 2009
Background Expression of recombinant proteins in green algal chloroplast holds substantial promise as a platform for the production of human therapeutic proteins.
Henry Ryan E, Muto Machiko, Mayfield Stephen P   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Introduction of recombinant antigens against Jembrana Disease Virus into plants [PDF]

, 2010
Jembrana disease virus (JDV) is a bovine lentivirus that causes an acute severe disease syndrome in banteng cattle (Bos javanicus) in Indonesia. In order to develop a vaccine, JDV capsid (CA) protein together with transactivator of transcription (Tat ...
Singh, Meenu
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Therapeutic proteins

, 2023
In this thisese, we discussed the possible factors that are linked with the history of therapeutic proteins, including their introduction, history, classification, production by recombinant technology, their importance in the health care system, and ...
Al Khalidi, Asmaa
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