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Glycosylation of recombinant protein therapeutics: control and functional implications
Glycobiology, 1991The discovery, development, production and clinical application of recombinant glycoproteins for therapeutic administration in humans has been, and continues to be, an area of intensive scientific and medical effort. This effort has engendered considerable interest in the biological and therapeutic implications of post-translational modifications ...
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Strategies for Modulation of Pharmacokinetics of Recombinant Therapeutic Proteins
Biology Bulletin Reviews, 2018The review describes current approaches to the optimization of pharmacokinetic properties of pharmaceutical proteins in order to achieve the maximum therapeutic effect. Examples of such technologies, including PEGylation, PEG mimetics, glycosylation, protein–protein fusion, and their advantages and limitations are discussed.
E. A. Zvonova +3 more
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[Advances of long-acting recombinant protein therapeutics].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019Some of the recombinant protein therapeutics with short half-life requires high frequent dose or injection, which results in poor patient compliance. This challenge has prompted the development of long-acting recombinant proteins in recent years. Four strategies and methods, including chemical modification, protein engineering, fusion proteins and ...
Ying, Wei +3 more
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Chapter 23. Second Generation Recombinant Therapeutic Proteins
1989Publisher Summary This chapter discusses the second-generation therapeutic proteins that have been generated and those investigations with the applied goal of improving a clinically-relevant property. The therapeutic use of antibodies to produce complement-fixation or cell-mediated lysis requires that the antibody have an appropriate heavy-chain ...
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Recombinant Production of Therapeutic Proteins
2023Parvez Singh Slathia +5 more
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Recombinant therapeutic proteins and translational errors
Trends in Biotechnology, 1993R F, Roserberg, R, Holliday
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly
The protein corona from nanomedicine to environmental science
Nature Reviews Materials, 2023Assist Prof Morteza Mahmoudi +2 more
exaly
[Recombinant proteins as therapeutic compounds in clinical oncology].
Therapeutische Umschau. Revue therapeutique, 2012The in vitro production of recombinant protein molecules has fostered a tremendous interest in their clinical application for treatment and support of cancer patients. Therapeutic proteins include monoclonal antibodies, interferons, and haematopoietic growth factors.
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