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Production of recombinant protein therapeutics in cultivated mammalian cells
Nature Biotechnology, 2004Cultivated mammalian cells have become the dominant system for the production of recombinant proteins for clinical applications because of their capacity for proper protein folding, assembly and post-translational modification. Thus, the quality and efficacy of a protein can be superior when expressed in mammalian cells versus other hosts such as ...
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Design of second generation therapeutic recombinant bone morphogenetic proteins
Cytokine & Growth Factor Reviews, 2009Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMPs used clinically.
Moulay Hicham, Alaoui-Ismaili +1 more
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Glycosylation of recombinant protein therapeutics: control and functional implications
Glycobiology, 1991The discovery, development, production and clinical application of recombinant glycoproteins for therapeutic administration in humans has been, and continues to be, an area of intensive scientific and medical effort. This effort has engendered considerable interest in the biological and therapeutic implications of post-translational modifications ...
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Acta Tropica, 2017
The inverse relationship between helminth infections and the development of immune-mediated diseases is a cornerstone of the hygiene hypothesis and studies were carried out to elucidate the mechanisms by which helminth-derived molecules can suppress immunological disorders.
Leonardo, Nascimento Santos +3 more
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The inverse relationship between helminth infections and the development of immune-mediated diseases is a cornerstone of the hygiene hypothesis and studies were carried out to elucidate the mechanisms by which helminth-derived molecules can suppress immunological disorders.
Leonardo, Nascimento Santos +3 more
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Recombinant Proteins and Peptides as Diagnostic and Therapeutic Reagents for Arthropod Allergies
Protein & Peptide Letters, 2007Domestic arthropods are chief sources of potent allergens that trigger sensitization and stimulate IgE-mediated allergies. Diagnosis and immunotherapy of arthropod allergies rely on the use of natural allergen extracts which are associated with low specificity and efficacy, the risk of anaphylactic reactions, and the extended period of treatment.
John Donnie A, Ramos +2 more
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Recombinant therapeutic proteins and translational errors
Trends in Biotechnology, 1993R F, Roserberg, R, Holliday
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Recombinant Production of Therapeutic Proteins
2023Parvez Singh Slathia +5 more
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Glycosylation control strategies for recombinant therapeutic proteins in CHO cells
BiochimieChinese hamster ovary (CHO) cells are widely employed as host cells for the production of recombinant therapeutic proteins (RTPs). Glycosylation, a crucial post-translational modification, significantly affects the function and quality of RTPs expressed in CHO cells.
Weifeng Wang +5 more
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[Advances of long-acting recombinant protein therapeutics].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019Some of the recombinant protein therapeutics with short half-life requires high frequent dose or injection, which results in poor patient compliance. This challenge has prompted the development of long-acting recombinant proteins in recent years. Four strategies and methods, including chemical modification, protein engineering, fusion proteins and ...
Ying, Wei +3 more
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