Results 11 to 20 of about 1,656,346 (308)

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. [PDF]

, 2015
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Kerber, Sarah, Zimmer, Gert, Miriam Bolz, Sarah Kerber (421868), Bolz, Miriam, Gerd Pluschke, Miriam Bolz (309717), Gert Zimmer, Sarah Kerber, Gerd Pluschke (7855), Pluschke, Gerd, Gert Zimmer (223023)   +11 more
core   +3 more sources

Protective immunity and safety of a genetically modified influenza virus vaccine. [PDF]

PLoS ONE, 2014
Recombinant influenza viruses are promising viral platforms to be used as antigen delivery vectors. To this aim, one of the most promising approaches consists of generating recombinant viruses harboring partially truncated neuraminidase (NA) segments. To
Rafael Polidoro Alves Barbosa, Ana Paula Carneiro Salgado, Cristiana Couto Garcia, Bruno Galvão Filho, Ana Paula de Faria Gonçalves, Braulio Henrique Freire Lima, Gabriel Augusto Oliveira Lopes, Milene Alvarenga Rachid, Andiara Cristina Cardoso Peixoto, Danilo Bretas de Oliveira, Marco Antônio Ataíde, Carla Aparecida Zirke, Tatiane Marques Cotrim, Érica Azevedo Costa, Gabriel Magno de Freitas Almeida, Remo Castro Russo, Ricardo Tostes Gazzinelli, Alexandre de Magalhães Vieira Machado   +17 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

A novel recombinant pseudorabies virus expressing parvovirus VP2 gene: Immunogenicity and protective efficacy in swine

Virology Journal, 2011
Background Porcine parvovirus (PPV) VP2 gene has been successfully expressed in many expression systems resulting in self-assembly of virus-like particles (VLPs) with similar morphology to the native capsid.
Chen Dishi, Shi Qian, Luo Yan, Yan Qigui, Xu Zhiwen, Guo Wanzhu, Chen Yang, Zhu Ling, Wang Xiaoyu   +8 more
doaj   +1 more source

A Novel Neurotoxin Gene ar1b Recombination Enhances the Efficiency of Helicoverpa armigera Nucleopolyhedrovirus as a Pesticide by Inhibiting the Host Larvae Ability to Feed and Grow. [PDF]

PLoS ONE, 2015
A recombinant Helicoverpa armigera nucleopolyhedrovirus (HearNPV), Ar1b-HearNPV, was constructed and identified as an improved bio-control agent of Helicoverpa armigera larvae.
Huan Yu, Jiao Meng, Jian Xu, Tong-Xian Liu, Dun Wang   +4 more
doaj   +1 more source

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9

Neuroscience Insights, 2019
Recombinant adeno-associated virus (rAAV) vectors have emerged as the safe vehicles of choice for long-term gene transfer in mammalian nervous system. Recombinant adeno-associated virus–mediated localized gene transfer in adult nervous system following ...
Asad Jan, Mette Richner, Christian B Vægter, Jens R Nyengaard, Poul H Jensen   +4 more
doaj   +1 more source

Mapping the sites of latency and reactivation by bovine herpesvirus 5 (BoHV-5) and a thymidine kinase-deleted BoHV-5 in lambs

Pesquisa Veterinária Brasileira, 2013
A thymidine kinase (tk)-deleted bovine herpesvirus 5 (BoHV-5tkΔ) was previously shown to establish latent infection and reactivate - even poorly - in a sheep model (Cadore et al. 2013). As TK-negative alphaherpesviruses are unlike to reactivate in neural
Gustavo C. Cadore, Gian Marcon, Mario Celso Sperotto Brum, Rudi Weiblen, Eduardo F. Flores   +4 more
doaj   +1 more source

A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1 [PDF]

, 2010
Background: The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry.
Dep Infectieziekten Immunologie, Robert P de Vries, Vries, R.P., de, Rigter, A., Rottier, P.J.M., Cornelissen, A.H.M., de Vries, R.P., Cornelissen, L.A.H.M., Alan Rigter, Cornelis A M de Haan, Strategic Infection Biology, de Haan, C.A.M., Haan, C.A.M., de, de Boer-Luijtze, E.A., Boer-Luijtze, E.A., de, Lisette A H M Cornelissen, Els A de Boer-Luijtze, Peter J M Rottier   +17 more
core   +3 more sources

A thymidine kinase-deleted bovine herpesvirus 5 establishes latent infection but reactivates poorly in a sheep model

Pesquisa Veterinária Brasileira, 2013
The ability of thymidine kinase (tk)-deleted recombinant bovine herpesvirus 5 (BoHV-5tkΔ) to establish and reactivate latent infection was investigated in lambs. During acute infection, the recombinant virus replicated moderately in the nasal mucosa, yet
Gustavo C. Cadore, Marcelo Weiss, Deniz Anziliero, Mário Celso S. Brum, Rudi Weiblen, Eduardo F. Flores   +5 more
doaj   +1 more source