Results 161 to 170 of about 99,506 (245)

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

<i>In vitro</i> and <i>in vivo</i> characterization of a novel HSV-1 H129 neurotracer recombinant reveals dose-dependent replication and spread dynamics. [PDF]

J Virol
Nua T, Velazquez-Rivera E, Sayin I, Ogu JC, Wu M, Xu X, Koyuncu OO.   +6 more
europepmc   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Temperature-Dependent Recombinase-Based Genetic Circuits. [PDF]

Int J Mol Sci
Gonzalez-Colell M, Gomes Del Castillo M, Palau Gauthier M, Macia J.   +3 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Structure, function, and applications of two novel phage recombinases from extreme environments. [PDF]

Nucleic Acids Res
Tarrant E, Cormack IG, Hunter CE, Werbowy O, Dorawa S, Wang L, Steen IH, Sandaa RA, Guðmundsdóttir EE, Ketelsen-Striberny B, Kaczorowska AK, Kaczorowski T, Pohl E, Freitag-Pohl S.   +13 more
europepmc   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Cell-free recombinase-integrated Boolean output system. [PDF]

Cell Syst
Chen J, Borison A, Densmore D, Wong WW.
europepmc   +1 more source

Conflicting adaptations in an inhibitory feedback circuit

The Journal of Physiology, EarlyView.
Abstract figure legend We studied activity‐dependent adaptation in the fruit fly Drosophila’s memory centre, the mushroom body. Here, excitatory Kenyon cells (KCs) receive feedback inhibition from the anterior paired lateral (APL) neuron. When KCs are artificially overactivated for 24 h, both KCs and APL reduce their sensitivity to excitation (‘↓ Exc’,
Gregor A. Bergmann, Melissa W. Tan, Katie Greenin‐Whitehead, Philippe J. Fischer, Thomas C. Cozens, Andrew C. Lin   +5 more
wiley   +1 more source

Construction and application of a genetically engineered mouse model of gastric adenocarcinoma. [PDF]

J Chin Med Assoc
Madeti Y, Chong X, Zhang X.
europepmc   +1 more source