Results 171 to 180 of about 99,506 (245)

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

The multiple roles of Ggt1-Cre in the generation of transgenic mice. [PDF]

Cell Mol Biol Lett
Feng ZS, Luo J, Chen XC, Zhao PP, Qiu ST, Wu CY, Huang XR, Sun BC, Guo XJ, Ye ZN, Yang C, Liu HF, Tang JX.   +12 more
europepmc   +1 more source

Generation of a Novel Col8a2P2A‐CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yong Yuan, Josiah Holt, Samuel Lorry, Yen‐Chiao Wang, Yueh‐Chiang Hu, Zhixing Ma, Adam Kaufman, Winston Kao, Diego G. Ogando, Chia‐Yang Liu   +9 more
wiley   +1 more source

Correction: Generation of a new Paneth cell-specific <i>Cre</i>-recombinase transgenic mouse line. [PDF]

Front Immunol
Garcia-Gonzalez N, Wallaeys C, Toussaint W, Hochepied T, Dewaele S, De Beul S, Van Loke R, Vandewalle J, Timmermans S, Blumberg RS, Libert C.   +10 more
europepmc   +1 more source

Contribution of Gli1⁺ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury. [PDF]

Adv Sci (Weinh)
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Wang H, Huang X, Mou J, Wang E, Li Y, Pu W, Xie Y, Guo X, Wang L, Chu M, Zhou B, Niu C.   +11 more
europepmc   +2 more sources

Development and Laboratory Validation of a Field‐Deployable CRISPR‐Cas12a eDNA Assay for Phylogeographic Lineage Detection in Arctic Char (Salvelinus alpinus)

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Environmental DNA (eDNA) tools are increasingly used for biodiversity monitoring, with most existing assays targeting species‐level identification. However, the use of eDNA to resolve intraspecific genetic variation remains rare and methodologically underdeveloped.
Darren J. Walsh, Rosaleen Hynes, Weili Guo, Cliodhna Surgenor, Paulo A. Prodöhl, Anne Parle‐McDermott   +5 more
wiley   +1 more source

A CRISPR-assisted passive microfluidic chip for rapid, visual detection of multiple respiratory viruses. [PDF]

Sci Rep
Li X, Guo J, Yang H, Wu Y, Xie Z, Li D.
europepmc   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, Volume 109, Issue 4, Page 615-629, April 2026.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

Correction: Genomic islands and plasmid borne antimicrobial resistance genes drive the evolution of high-risk, ST-131 uropathogenic E. coli NS30. [PDF]

BMC Genomics
Peketi ASK, Nagaraja V, Bulagonda EP.
europepmc   +1 more source

Repeated Stress Escalates Aggression and Activity in Fronto‐Limbic Regions in Cntnap2−/− Mice

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
Stress induced aggression emerges only after repeated restraint stress in Cntnap2−/− mice. Neuronal activity mapping revealed stress‐evoked activation in the lateral septum, lateral habenula, lateral hypothalamus, nucleus accumbens, and prefrontal cortex, with aggressive behavior positively correlating specifically with activity in the lateral septum ...
Caroline H. Hertweck, Chase A. Carter, Sarah S. McDaniel, Pierre Llorach, Hayleigh E. Tilton, Anish Kodali, Daniel J. Christoffel, Jessica J. Walsh   +7 more
wiley   +1 more source