Results 181 to 190 of about 99,506 (245)

Development of a point-of-care dual one-step recombinase-aided PCR assay for rapid identification of <i>Mycobacterium tuberculosis gyrA</i> mutations conferring fluoroquinolone resistance. [PDF]

Front Microbiol
Liu X, Peng K, Li Y, Jiao S, Wu J, Zhang D, Gao S, Xiang Y, Ren J, Ma Q, Li X, Zhao Z, Han Z, Shen X, Ma X, Tie Y.   +15 more
europepmc   +1 more source

Making Molecular Diagnostics Faster

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 272-280, April 2026.
ABSTRACT Background Over the past 40 years, molecular diagnostic methods have evolved from multi‐step, time‐consuming protocols towards either rapid targeted tests or expansive, massively parallel testing. Aims Here we consider the speed limits of targeted molecular diagnostics, considering the three sequential required steps: nucleic acid preparation,
Carl T. Wittwer, Luming Zhou, Felix Ye, Adam Millington, Adrian de Cola, Noriko Kusukawa   +5 more
wiley   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications. [PDF]

Adv Sci (Weinh)
Chen H, Liu Z, Shu Q, Zhou B.
europepmc   +1 more source

CRISPR‐Enhanced RAA‐SHERLOCK Assay for Point‐of‐Care Detection of Cyprinid Herpesvirus‐3: Development, Validation and Clinical Application

Journal of Fish Diseases, Volume 49, Issue 4, April 2026.
ABSTRACT Koi herpesvirus disease (KHVD), caused by Cyprinid herpesvirus‐3 (CyHV‐3), poses a significant threat to global aquaculture due to its high mortality rates and economic impact. Current diagnostic methods, such as PCR, are limited by equipment dependency and procedural complexity, hindering point‐of‐care (POC) applications.
Hatem Soliman, Naveed Akram, Mona Saleh
wiley   +1 more source

Porphyromonas gingivalis–Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein‐1 Canonical Signaling

Molecular Oral Microbiology, Volume 41, Issue 2, Page 85-93, April 2026.
ABSTRACT Periodontal bacterial pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules are periodontal bacterium Porphyromonas gingivalis–derived virulence lipids, for example, phosphoglycerol ...
Chiaki Yamada, Gang Peng, James A. Johnson Jr., Amilia Nusbaum, Natasha Sanz, Hawra AlQallaf, Frank Nichols, Alexandru Movila   +7 more
wiley   +1 more source

RPA-CRISPR/Cas12a-based detection of Pasteurella multocida: establishment and initial application. [PDF]

Front Vet Sci
Yan C, Li X, Chen R, Wu Q, Zhuang Y, Li N, Ma X, Chu Y, Shi H, Fu Q, Yang L.   +10 more
europepmc   +1 more source

ZNF384‐Driven Fibulin‐1 Exacerbates Vascular Stiffness via TGF‐β/Smad3‐Mediated Senescence and Fibrosis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This article elucidates the regulatory molecular mechanisms of Fibulin‐1 (Fbln1) in vascular stiffness and explores potential therapeutic interventions. Zinc Finger Protein 384 (ZNF384) binds to the Fbln1 promoter, driving its expression. Fbln1 activates the TGF‐β/Smad3 axis, promoting vascular smooth muscle cell (VSMC) senescence and collagen ...
Dan Yan, Tianyi ji, Xiaolu Liang, Mandi Luo, Yi Huang, Pengcheng Luo, Zhen Yang, Le Zhang, Tao Li, Yong Ping Bai, Cuntai Zhang, Lei Ruan   +11 more
wiley   +1 more source

Isothermal nucleic acid amplification techniques: A comprehensive overview on their principle & applications as alternative to PCR. [PDF]

Pract Lab Med
Amare Amdiyee A, Sisay Tessema T.
europepmc   +1 more source

Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine‐Induced Kidney Injury via OXCT1‐Mediated Ketolysis in Mice

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
1,3‐Butanediol is a ketone body precursor that is directly converted into the ketone bodies, β‐hydroxybutyrate (BHB), in the liver. When renal ketolysis, regulated by 3‐oxoacid CoA‐transferase 1 (OXCT1), is preserved, BHB supplementation exerts renoprotective effects.
Shoji Omachi, Sho Sugahara, Junya Horiguchi, Mako Yasuda‐Yamahara, Shogo Kuwagata, Kosuke Yamahara, Yuki Tanaka‐Sasaki, Shogo Ida, Tetsuro Kusaba, Benjamin D. Humphreys, Kenji Kufukihara, Jin Nakahara, Masami Chin‐Kanasaki, Shinji Kume   +13 more
wiley   +1 more source

Rapid Forensic DNA Profiling via Real-Time Recombinase Polymerase Amplification of InDel Markers. [PDF]

Biosensors (Basel)
De Keyzer L, Škevin S, Deserranno K, Deforce D, Van Nieuwerburgh F.   +4 more
europepmc   +1 more source