Results 211 to 220 of about 99,506 (245)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Rapid detection of <i>Hemophilus influenzae</i> and <i>Streptococcus pneumoniae</i> simultaneously using a duplex recombinase-aided amplification assay directly from invasive clinical samples. [PDF]

Front Cell Infect Microbiol
Zhou L, Xia Y, Feng Y, Du B, Huang X, Xu W, Li J, Fang F, Meng C, Yu L, Ma L, Xue G, Yuan J.   +12 more
europepmc   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Establishment and field validation of a rapid on-site recombinase polymerase amplification-lateral flow assay for BRSV and BVDV. [PDF]

Front Vet Sci
Zhao Z, Guo Y, Liu S, Hao L, Sun X, Xiang Y, Wang N, Meng X, Sun H, Yue S, Gong P, Cao L.   +11 more
europepmc   +1 more source

A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus. [PDF]

Genesis
Kelleher AM, Kim HI, Bayammagari GS, Davis DJ, Spencer TE.   +4 more
europepmc   +1 more source

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells. [PDF]

J Exp Med
Farré Díaz C, Kabrani E, Winkler W, Blanc E, Wollert-Wulf B, Salomon C, Wunderlich FT, Beule D, Janz M, Rajewsky K.   +9 more
europepmc   +1 more source

Novel Recombinase Polymerase Amplification Assay Is Sensitive for Detection of Macrolide Resistance Genes Relevant to Bovine Respiratory Disease Management in Feedlot Calves. [PDF]

Vet Sci
Funk T, McLeod L, Conrad CC, Zaheer R, Otto SJG, Waldner CL, McAllister TA.   +6 more
europepmc   +1 more source

Epigenetic silencing is a barrier to editing the X chromosome using the SEC-based CRISPR/Cas9 knock-in protocol in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Iyer R, Ferreria S, Guvvala L, Borden H, Arora A, Shirsat R, Doonan R.   +6 more
europepmc   +1 more source