Results 21 to 30 of about 1,224,382 (402)
Molecular Cell, 2012 The MCM proteins are best known for their role in DNA replication, MCM2-7 forming the replicative helicase. Now, two reports in this issue of Molecular Cell, Nishimura et al. (2012) and Lutzmann et al. (2012) show the less well understood MCM8 and MCM9 to be crucial for effective homologous recombination.
Guillaume Guilbaud, Julian E. Sale
openaire +3 more sources
Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution
mBio, 2020 HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen +7 more
doaj +1 more source
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1
Nature Communications, 2023 Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek +7 more
doaj +1 more source
Pan-cancer landscape of homologous recombination deficiency
Nature Communications, 2020 Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen +3 more
semanticscholar +1 more source
Common envelopes in massive stars II: The distinct roles of hydrogen and helium recombination [PDF]
, 2022 The role of recombination during a common-envelope event has been long debated. Many studies have argued that much of hydrogen recombination energy, which is radiated in relatively cool and optically-thin layers, might not thermalise in the envelope. On the other hand, helium recombination contains 30% of the total recombination energy, and occurs much
arxiv +1 more source
Frontiers in Genetics, 2021 The formation of hybrid sterility is an important stage of speciation. The voles of the genus Microtus, which is the most speciose genus of rodents, provide a good model for studying the cytological mechanisms of hybrid sterility.
Tatiana I. Bikchurina +7 more
doaj +1 more source
Determination of the trap-assisted recombination strength in polymer light emitting diodes [PDF]
, 2011 The recombination processes in poly(p-phenylene vinylene) based polymer light-emitting diodes (PLEDs) are investigated. Photogenerated current measurements on PLED device structures reveal that next to the known Langevin recombination also trap-assisted ...
Gert-Jan A. H. Wetzelaer +6 more
core +4 more sources
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]
, 2020 The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat +55 more
core +2 more sources
RDP4: Detection and analysis of recombination patterns in virus genomes
Virus Evolution, 2015 RDP4 is the latest version of recombination detection program (RDP), a Windows computer program that implements an extensive array of methods for detecting and visualising recombination in, and stripping evidence of recombination from, virus genome ...
D. Martin +4 more
semanticscholar +1 more source
Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells. [PDF]
, 1993 A large number of animal and human carcinogens without apparent genotoxic activity exist (nonmutagenic carcinogens) that are difficult or impossible to detect with the currently used short-term tests.
Schiestl, RH
core +2 more sources