Results 31 to 40 of about 711,475 (257)

Meiotic Crossover Patterning

Frontiers in Cell and Developmental Biology, 2021
Proper number and placement of meiotic crossovers is vital to chromosome segregation, with failures in normal crossover distribution often resulting in aneuploidy and infertility.
Nila M. Pazhayam, Carolyn A. Turcotte, Jeff Sekelsky, Jeff Sekelsky, Jeff Sekelsky   +4 more
doaj   +1 more source

How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture

Journal of Virology
HIV-1 uses neighboring sequences as transcription start sites and generates multiple unspliced transcripts, including two major transcripts with three guanosines (3G) or one guanosine (1G) at the 5′ end. Although only differing by 2-nt, 3G RNA and 1G RNA
Olga A. Nikolaitchik, Akhil Chameettachal, Saiful Islam, Zetao Cheng, Krista Delviks-Frankenberry, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Viruses
During retrovirus assembly, Gag packages unspliced viral RNA as the virion genome. Genome packaging is usually specific with occasional exceptions of cross-packaging RNA from distantly related retroviruses.
Zetao Cheng, Olga A. Nikolaitchik, Alice Duchon, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Development of a Complementation Assay to Monitor Pan-Coronavirus 3C-like Protease Activity

Viruses
Coronaviruses pose a global pandemic threat, making development of a pan-coronavirus inhibitor crucial for preparedness and containment in the event of a new coronavirus outbreak.
Akhil Chameettachal, Alice Duchon, Matthew A. Brown, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

eLife, 2021
Although recombination is accepted to be common in bacteria, for many species robust phylogenies with well-resolved branches can be reconstructed from whole genome alignments of strains, and these are generally interpreted to reflect clonal relationships.
Thomas Sakoparnig, Chris Field, Erik van Nimwegen   +2 more
doaj   +1 more source

Electrical and photoelectrical properties of MoN/n-Si surface-barrier structures [PDF]

Радиофизика и электроника, 2019
Subject and purpose. The subject of research is the electrical and photoelectric properties of the МoN/n-Si heterostructure fabricated for the first time by means of the deposition of thin film of molybdenum nitride (n-type conductivity) by the reactive ...
M.M. Solovan, P.D. Maryanchuk
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution [PDF]

, 2010
Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood.
Skinner, Benjamin M., Bunzey, Sydney K., Ellegren, Hans, Völker, Martin, Backström, Niclas, Langley, Elizabeth J, Griffin, Darren K., Skinner, Benjamin M, Bunzey, Sydney K, Griffin, Darren K, Ellegren, Hans,, Backström, Niclas,   +11 more
core   +1 more source

One generation of evolution in the three slightly different selection-recombination-mutation schemes.

, 2022
Nodes represent individuals and colors genotypes, with green and blue nodes being viable and red nodes unfit. The arrows show the lineages from the ancestors to the descendants.
Alexander Klug (7252493), Joachim Krug (155030)   +1 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source