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Frontiers in Genetics, 2021 The formation of hybrid sterility is an important stage of speciation. The voles of the genus Microtus, which is the most speciose genus of rodents, provide a good model for studying the cytological mechanisms of hybrid sterility.
Tatiana I. Bikchurina +7 more
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SARS-CoV-2: from its discovery to genome structure, transcription, and replication
Cell & Bioscience, 2021 SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant ...
Ayslan Castro Brant +4 more
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Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity
Frontiers in Pharmacology, 2021 A serious adverse effect of cancer therapies is cardiovascular toxicity, which significantly limits the widespread use of antineoplastic agents. The promising new field of cardio-oncology offers the identification of potent anti-cancer therapeutics that ...
Zoltán Szabó +4 more
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Sequence diversity and potential recombination events in the coat protein gene of Apple stem pitting virus. [PDF]
, 2011 The variability of the Apple stem pitting virus (ASPV) coat protein (CP) gene was investigated. The CP gene of ten virus isolates from apple and pear trees was sequenced.
Malinowski, Tadeusz +4 more
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Frontiers in Cell and Developmental Biology, 2020 Meiotic recombination is initiated by Spo11-catalyzed DNA double-strand breaks (DSBs) that are promoted by histone modifications and histone modifying enzymes. Herein we investigated the role of histone H3 lysine 56 acetylation (H3K56ac) located near the
Zsolt Karányi +3 more
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Non-Contiguous Protein Recombination [PDF]
, 2013 Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
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The effects of recombination rate on the distribution and abundance of transposable elements [PDF]
, 2008 Transposable elements (TEs) often accumulate in regions of the genome with suppressed recombination. But it is unclear whether this pattern reflects a reduction in the efficacy of selection against deleterious insertions or a relaxation of ectopic ...
Charlesworth, Brian, Dolgin, Elie S.
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Lineage specific recombination rates and microevolution in Listeria monocytogenes [PDF]
, 2008 Background: The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread lineages (termed lineages I and II) and an uncommon lineage ...
Fortes, Esther D +4 more
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Recombination modulates how selection affects linked sites in Drosophila [PDF]
, 2012 One of the most influential observations in molecular evolution has been a strong association between regional recombination rate and amount of nucleotide polymorphism in those genomic regions, interpreted as evidence for ubiquitous natural selection ...
Caiti S. Smukowski +8 more
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Bayesian modeling of recombination events in bacterial populations [PDF]
, 2008 Background: We consider the discovery of recombinant segments jointly with their origins within multilocus DNA sequences from bacteria representing heterogeneous populations of fairly closely related species.
Marttinen, P. +21 more
core +1 more source