Results 11 to 20 of about 711,475 (257)

sequenceLDhot: Detecting Recombination Hotspots. [PDF]

, 2006
Motivation: There is much local variation in recombination rates across the human genome—with the majority of recombination occuring in recombination hotspots—short regions of around ~2 kb in length that have much higher recombination rates than ...
Fearnhead, Paul
core   +4 more sources

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Nature Communications, 2023
Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek, Simone Kunzelmann, Andrew G. Purkiss, Mariana Silva Dos Santos, James I. MacRae, Ian A. Taylor, Kasper Fugger, Stephen C. West   +7 more
doaj   +1 more source

Determinants of selectivity in Xer site-specific recombination [PDF]

, 1996
A remarkable property of some DNA-binding proteins that can interact with and pair distant DNA segments is that they mediate their biological function only when their binding sites are arranged in a specific configuration. Xer site-specific recombination
Blakely, G, Sherratt, D
core   +1 more source

Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

Computational and Structural Biotechnology Journal, 2021
Flap endonuclease 1 (FEN1) is an important component of the intricate molecular machinery for DNA replication and repair. FEN1 is a structure-specific 5′ nuclease that cleaves nascent single-stranded 5′ flaps during the maturation of Okazaki fragments ...
Mohamed A. Sobhy, Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio, Samir M. Hamdan   +5 more
doaj   +1 more source

Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]

, 2013
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E, Baca Jeannie, Vladimir Novitsky, Essex, M., Baca, Jeannie, Mary F McLane, Kapiga, Saidi H., Novitsky, Vladimir, Saidi H Kapiga, McLane, Mary F, M Essex, Ireen E Kiwelu, McLane, Mary, Essex, M, Jeannie Baca, Kiwelu Ireen E., Novitsky Vladimir, Manongi, Rachel, Manongi Rachel, Rachel Manongi, Kapiga, Saidi H, Margolin Lauren, Essex M., John Shao, Kiwelu, Ireen E., Noel Sam, Sam Noel, Lauren Margolin, McLane Mary F., Margolin, Lauren, Sam, Noel, Shao John, Kapiga Saidi H., Shao, John   +33 more
core   +1 more source

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source

Personalized genome structure via single gamete sequencing

Genome Biology, 2021
Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s genome,
Ruqian Lyu, Vanessa Tsui, Davis J. McCarthy, Wayne Crismani   +3 more
doaj   +1 more source

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

Bioactive Materials, 2023
As a renewable and sustainable source for energy, environment, and biomedical applications, microalgae and microalgal biodiesel have attracted great attention.
Guoxia Zheng, Yutong Cui, Ling Lu, Ming Guo, Xuejun Hu, Lin Wang, Shuping Yu, Shenxia Sun, Yuancheng Li, Xingcai Zhang, Yunhua Wang   +10 more
doaj   +1 more source

Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length 'imprecise' intermediates [PDF]

, 2014
Recombination in enteroviruses provides an evolutionary mechanism for acquiring extensive regions of novel sequence, is suggested to have a role in genotype diversity and is known to have been key to the emergence of novel neuropathogenic variants of ...
David J Evans, Woodman, Andrew, Andrew Woodman, Kym Lowry (222718), Jonathan Cook (3435386), Andrew Woodman (577477), Cook, Jonathan, Cook, Jonathan P., David J. Evans (208308), Lowry, Kym, David J. Evans, Evans, David J., Kym Lowry, Jonathan Cook, Lowry Kym, Woodman Andrew, Evans David J., Cook Jonathan, Evans, David J.; id_orcid   +18 more
core   +1 more source

Recombination and its impact on the genome of the haplodiploid parasitoid wasp Nasonia [PDF]

, 2010
Homologous meiotic recombination occurs in most sexually reproducing organisms, yet its evolutionary advantages are elusive. Previous research explored recombination in the honeybee, a eusocial hymenopteran with an exceptionally high genome-wide ...
Gibson, Joshua D., Gadau Jürgen, Kennedy Kathleen, Koevoets Tosca, Gibson Joshua D., Werren, John H., Koevoets, Tosca, van de Zande, Louis, Gadau, Jürgen, Shuker David M., Niehuis, Oliver, Joshua D Gibson, Leo W Beukeboom, David M. Shuker, Andrea K Judson, David Duggan, David M Shuker, Beukeboom Leo W., van de Zande Louis, Christopher A Desjardins, Bart A. Pannebakker, Rosenberg, Michael S., Duggan, David, Kathleen Kennedy, Shuker, David Michael, Gadau, Juergen, van de Zande, Louis; id_orcid, Andrea K. Judson, John H Werren, Judson, Andrea K., Kennedy, Kathleen, Pannebakker Bart A., Michael S. Rosenberg, Tosca Koevoets, Louis van de Zande, Beukeboom, Leo W., Werren John H., John H. Werren, Jürgen Gadau, Pannebakker, Bart A., Duggan David, Niehuis Oliver, Christopher A. Desjardins, Leo W. Beukeboom, Desjardins, Christopher A., Oliver Niehuis, Joshua D. Gibson, Rosenberg Michael S., Bart A Pannebakker, Michael S Rosenberg, Judson Andrea K., Shuker, David M., Desjardins Christopher A.   +52 more
core   +2 more sources