Results 11 to 20 of about 631,742 (318)

Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome

Computational and Structural Biotechnology Journal, 2021
Throughout evolution, DNA transposons provide a recurrent supply of genetic information to give rise to novel gene functions by fusion of their transposase domain to various domains of host-encoded proteins.
Márton Miskei, Adrienn Horváth, Lívia Viola, Laura Varga, Éva Nagy, Orsolya Feró, Zsolt Karányi, Jason Roszik, Csaba Miskey, Zoltán Ivics, Lóránt Székvölgyi   +10 more
doaj   +1 more source

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Nature Communications, 2023
Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek, Simone Kunzelmann, Andrew G. Purkiss, Mariana Silva Dos Santos, James I. MacRae, Ian A. Taylor, Kasper Fugger, Stephen C. West   +7 more
doaj   +1 more source

Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

Computational and Structural Biotechnology Journal, 2021
Flap endonuclease 1 (FEN1) is an important component of the intricate molecular machinery for DNA replication and repair. FEN1 is a structure-specific 5′ nuclease that cleaves nascent single-stranded 5′ flaps during the maturation of Okazaki fragments ...
Mohamed A. Sobhy, Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio, Samir M. Hamdan   +5 more
doaj   +1 more source

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source

Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]

, 2013
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E, Baca Jeannie, Vladimir Novitsky, Essex, M., Baca, Jeannie, Mary F McLane, Kapiga, Saidi H., Novitsky, Vladimir, Saidi H Kapiga, McLane, Mary F, M Essex, Ireen E Kiwelu, McLane, Mary, Essex, M, Jeannie Baca, Kiwelu Ireen E., Novitsky Vladimir, Manongi, Rachel, Manongi Rachel, Rachel Manongi, Kapiga, Saidi H, Margolin Lauren, Essex M., John Shao, Kiwelu, Ireen E., Noel Sam, Sam Noel, Lauren Margolin, McLane Mary F., Margolin, Lauren, Sam, Noel, Shao John, Kapiga Saidi H., Shao, John   +33 more
core   +1 more source

Personalized genome structure via single gamete sequencing

Genome Biology, 2021
Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s genome,
Ruqian Lyu, Vanessa Tsui, Davis J. McCarthy, Wayne Crismani   +3 more
doaj   +1 more source

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Recombination: Homologous recombination branches out [PDF]

Current Biology, 2001
Homologous recombination can be divided into three key steps: strand exchange, branch migration and resolution. The identification of a protein complex that catalyses branch migration and Holliday junction resolution argues that the mechanism of homologous recombination is conserved from bacteria to man.
openaire   +2 more sources

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

Bioactive Materials, 2023
As a renewable and sustainable source for energy, environment, and biomedical applications, microalgae and microalgal biodiesel have attracted great attention.
Guoxia Zheng, Yutong Cui, Ling Lu, Ming Guo, Xuejun Hu, Lin Wang, Shuping Yu, Shenxia Sun, Yuancheng Li, Xingcai Zhang, Yunhua Wang   +10 more
doaj   +1 more source

Lineage specific recombination rates and microevolution in Listeria monocytogenes [PDF]

, 2008
Background: The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread lineages (termed lineages I and II) and an uncommon lineage ...
Fortes, ED, Fortes, Esther D, Didelot, X, Nightingale, KK, Didelot, Xavier, Wiedmann, Martin, den Bakker, Henk C., Nightingale, Kendra K, Den Bakker, HC, Wiedmann, M   +9 more
core   +1 more source