Results 11 to 20 of about 1,358,732 (333)

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]

, 2020
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat, Ambrozkiewicz, Mateusz C, Beier, Kevin T, Benseler, Fritz, Brose, Nils, Burgess, Harold A, Cepko, Constance L, Chen, Cui, Cloutier, Jean-François, Craig, Ann Marie, Dumontier, Emilie, Eroglu, Cagla, Falkner, Susanne, Furlanis, Elisabetta, Goebbels, Sandra, Gomez, Andrea M, Hoshina, Naosuke, Huang, Wei-Hsiang, Hutchison, Mary Anne, Itoh-Maruoka, Yu, Kaeser, Pascal S, Kawabe, Hiroshi, Kay, Jeremy N, Lavery, Laura A, Li, Wei, Lu, Wei, Luo, Lin, Luo, Liqun, Mandai, Kenji, Maruo, Tomohiko, McBain, Chris J, Motohashi, Junko, Nave, Klaus-Armin, Pai, Emily Ling-Lin, Pelkey, Kenneth A, Pereira, Ariane, Philips, Thomas, Prado, Marco AM, Prado, Vania F, Rothstein, Jeffrey, Rubenstein, John LR, Saher, Gesine, Sakimura, Kenji, Sanes, Joshua R, Scheiffele, Peter, Sinclair, Jennifer L, Stogsdill, Jeff A, Takai, Yoshimi, Traunmüller, Lisa, Umemori, Hisashi, Verhage, Matthijs, Wang, Jiexin, Wortel, Joke, You, Wenjia, Yuzaki, Michisuke, Zoghbi, Huda Yahya   +55 more
core   +2 more sources

Evolution of the recombination regulator PRDM9 in minke whales

BMC Genomics, 2022
Background PRDM9 is a key regulator of meiotic recombination in most metazoans, responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein recognizes and binds specific target motifs via its array of C2H2 zinc-fingers encoded by a ...
Elena Damm, Kristian K. Ullrich, William B. Amos, Linda Odenthal-Hesse   +3 more
doaj   +1 more source

Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome

Computational and Structural Biotechnology Journal, 2021
Throughout evolution, DNA transposons provide a recurrent supply of genetic information to give rise to novel gene functions by fusion of their transposase domain to various domains of host-encoded proteins.
Márton Miskei, Adrienn Horváth, Lívia Viola, Laura Varga, Éva Nagy, Orsolya Feró, Zsolt Karányi, Jason Roszik, Csaba Miskey, Zoltán Ivics, Lóránt Székvölgyi   +10 more
doaj   +1 more source

RDP5: a computer program for analyzing recombination in, and removing signals of recombination from, nucleotide sequence datasets

Virus Evolution, 2020
For the past 20 years, the recombination detection program (RDP) project has focused on the development of a fast, flexible, and easy to use Windows-based recombination analysis tool.
D. Martin, A. Varsani, P. Roumagnac, G. Botha, Suresh Maslamoney, Tiana C. Schwab, Zena Kelz, Venkatesh Kumar, B. Murrell   +8 more
semanticscholar   +1 more source

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Nature Communications, 2023
Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek, Simone Kunzelmann, Andrew G. Purkiss, Mariana Silva Dos Santos, James I. MacRae, Ian A. Taylor, Kasper Fugger, Stephen C. West   +7 more
doaj   +1 more source

Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

Computational and Structural Biotechnology Journal, 2021
Flap endonuclease 1 (FEN1) is an important component of the intricate molecular machinery for DNA replication and repair. FEN1 is a structure-specific 5′ nuclease that cleaves nascent single-stranded 5′ flaps during the maturation of Okazaki fragments ...
Mohamed A. Sobhy, Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio, Samir M. Hamdan   +5 more
doaj   +1 more source

The Accelerated Recombination, and the ACBAR and WMAP data [PDF]

, 2008
We have investigated the deviation from the standard recombination process, using the ACBAR 2008 and the WMAP 3 year data. In this investigation, we have considered the possibility of the accelerated recombination as well as the delayed recombination. We
Doroshkevich, Fixsen, Hinshaw, Jaiseung Kim, Pavel Naselsky, Peebles, Reichardt   +6 more
core   +1 more source

Pan-cancer landscape of homologous recombination deficiency

Nature Communications, 2020
Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen, John W M Martens, Arne van Hoeck, E. Cuppen   +3 more
semanticscholar   +1 more source

Electron-Ion Recombination Rate Coefficients and Photoionization Cross Sections for Astrophysically Abundant Elements VI. Ni II [PDF]

, 2001
We present the first detailed ab initio quantum mechanical calculations for total and state-specific recombination rate coefficients for e + Ni III --> Ni II.
Bautista M. A., Hummer D. G., Manuel A. Bautista, Seaton M. J., Sultana N. Nahar, Zhang H. L.   +5 more
core   +2 more sources

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source