Results 51 to 60 of about 711,475 (257)
Viruses, 2022 Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork ...
Xiaoyu Niu, Qiuhong Wang
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Location and Identification on Chromosome 3B of Bread Wheat of Genes Affecting Chiasma Number
Plants, 2022 Understanding meiotic crossover (CO) variation in crops like bread wheat (Triticum aestivum L.) is necessary as COs are essential to create new, original and powerful combinations of genes for traits of agronomical interest.
Benoit Darrier +7 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Single-crossover recombination and ancestral recombination trees [PDF]
, 2011 von Wangenheim U. Single-crossover recombination and ancestral recombination trees. Bielefeld: Universität Bielefeld; 2011.Modeling the process of recombination in the deterministic limit of an infinite population leads to a large coupled nonlinear ...
von Wangenheim, Ute
core
Regional differences in recombination hotspots between two chicken populations [PDF]
, 2010 Background Although several genetic linkage maps of the chicken genome have been published, the resolution of these maps is limited and does not allow the precise identification of recombination hotspots. The availability of more than 3.2 million SNPs in
Veenendaal, A. +14 more
core +1 more source
Role of Diversity and Recombination in the Emergence of Chilli Leaf Curl Virus
Pathogens, 2022 Chilli leaf curl virus (ChiLCV), (Genus Begomovirus, family Geminiviridae) and associated satellites pose a serious threat to chilli production, worldwide.
Megha Mishra +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
Frontiers in Immunology, 2018 Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology.
Lilla Hornyák +8 more
doaj +1 more source
Viruses, 2021 Porcine circovirus-like virus (PCLV) is a type of circular Rep-encoding single-stranded DNA virus and may be associated with the development of diarrheal symptoms in pigs.
Kankan Yang +10 more
doaj +1 more source