Results 31 to 40 of about 8,966 (220)

Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]

, 2010
Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna, Grzesiuk, Elzbieta, A. Sikora, J. Nieminuszczy, Mielecki, Damian, D. Mielecki, A. Chojnacka, Nieminuszczy, Jadwiga, Wrzesiński, Michał, M. Wrzesinski, E. Grzesiuk, Chojnacka, Aleksandra   +11 more
core   +1 more source

Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. [PDF]

PLoS ONE, 2007
DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication.
Sudha Sharma, Robert M Brosh
doaj   +1 more source

Plant DNA repair and recombination on the French Mediterranean [PDF]

EMBO reports, 2007
This EMBO Workshop on Plant DNA Repair & Recombination took place between 31 May and 3 June 2007, in Presqu'ile de Giens, France, and was organized by B. Hohn, A. Levy, H. Puchta, D. Shippen, C. Well and C. White. ![][1] Two factors motivate research in plant DNA repair and recombination today: the unique tools that plants offer for understanding ...
Gregory P, Copenhaver, Paul J J, Hooykaas   +1 more
openaire   +2 more sources

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways [PDF]

Microbial Cell, 2019
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be manipulated. Cellular assays comprise genetic, molecular, and cytological reporters.
Klein, Hannah, Bačinskaja, Giedrė, Che, Jun, Cheblal, Anais, Elango, Rajula, Epshtein, Anastasiya, Fitzgerald, Devon, Gómez-González, Belén, Khan, Sharik, Kumar, Sandeep, Leland, Bryan, Marie, Léa, Mei, Qian, Miné-Hattab, Judith, Piotrowska, Alicja, Polleys, Erica, Putnam, Christopher, Radchenko, Elina, Ait Saada, Anissia, Sakofsky, Cynthia, Shim, Eun Yong, Stracy, Mathew, Xia, Jun, Yan, Zhenxin, Yin, Yi, Aguilera, Andres, Argueso, Juan Lucas, Freudenreich, Catherine, Gasser, Susan, Gordenin, Dmitry, Haber, James, Ira, Grzegorz, Jinks-Robertson, Sue, King, Megan, Kolodner, Richard, Kuzminov, Andrei, Lambert, Sarah Ae, Lee, Sang Eun, Miller, Kyle, Mirkin, Sergei, Petes, Thomas, Rosenberg, Susan, Rothstein, Rodney, Symington, Lorraine, Zawadzki, Pawel, Kim, Nayun, Lisby, Michael, Malkova, Anna   +47 more
openaire   +10 more sources

Parental histone distribution and location of the replication obstacle at nascent strands control homologous recombination

Cell Reports, 2023
Summary: The advance and stability of replication forks rely on a tight co-regulation of DNA synthesis and nucleosome assembly. We show that mutants affected in parental histone recycling are impaired in the recombinational repair of the single-stranded ...
Cristina González-Garrido, Félix Prado
doaj   +1 more source

Transcript-RNA-templated DNA recombination and repair [PDF]

Nature, 2014
Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homologous recombination can also occur ...
Keskin, Havva, Shen, Ying, Huang, Fei, Patel, Mikir, Yang, Taehwan, Ashley, Katie, Mazin, Alexander V., Storici, Francesca   +7 more
openaire   +2 more sources

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein [PDF]

, 2014
MUS81-EME1 is a conserved structure-selective endonuclease with a preference for branched DNA substrates in vitro that correspond to intermediates of DNA repair.
Rouse, John, Macartney, Thomas, Nair, Nidhi, Castor, Dennis   +3 more
core   +1 more source

BRCA1-BARD1: the importance of being in shape

Molecular & Cellular Oncology, 2019
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin, Ruth M. Densham, Joanna R. Morris   +2 more
doaj   +1 more source

Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]

Network Biology, 2020
There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad, Mohamed Soliman Elshikh, Haris Lokvancic   +2 more
doaj  

ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. [PDF]

PLoS ONE, 2010
Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA
Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar, Satoshi Tashiro   +10 more
doaj   +1 more source