Results 21 to 30 of about 8,966 (220)
DNA helicases in homologous recombination repair
Current Opinion in Genetics & Development, 2021 Helicases are in the spotlight of DNA metabolism and are critical for DNA repair in all domains of life. At their biochemical core, they bind and hydrolyze ATP, converting this energy to translocate unidirectionally, with different strand polarities and substrate binding specificities, along one strand of a nucleic acid.
Branzei D, Szakal B
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Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella
Bio-Protocol, 2019 Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis +2 more
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Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2009 Peroxiredoxins (Prxs) constitute a family of thiol-specific peroxidases that utilize cysteine (Cys) as the primary site of oxidation during the reduction of peroxides.
Ismail Iraqui +6 more
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Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]
, 2006 The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC +5 more
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Recombinational DNA repair and human disease [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002 We review the genes and proteins related to the homologous recombinational repair (HRR) pathway that are implicated in cancer through either genetic disorders that predispose to cancer through chromosome instability or the occurrence of somatic mutations that contribute to carcinogenesis.
Thompson, Larry H., Schild, David
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ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair [PDF]
, 2008 Background: The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell
Davey, Ross, Stordal, Britta
core +1 more source
Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete. [PDF]
PLoS ONE, 2013 Antigenic variation through targeted DNA rearrangements provides a powerful diversity generating mechanism that allows a variety of pathogens to stay one step ahead of acquired immunity in their hosts.
Rupali Walia, George Chaconas
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PLoS ONE, 2011 The cohesin complex is required for the cohesion of sister chromatids and for correct segregation during mitosis and meiosis. Crossover recombination, together with cohesion, is essential for the disjunction of homologous chromosomes during the first ...
Antoine Baudrimont +8 more
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Microorganisms, 2023 Homologous recombination repairs potentially lethal DNA lesions such as double-strand DNA breaks (DSBs) and single-strand DNA gaps (SSGs). In Escherichia coli, DSB repair is initiated by the RecBCD enzyme that resects double-strand DNA ends and loads ...
Ksenija Zahradka +3 more
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DNA in 3R: Repair, Replication, and Recombination [PDF]
Molecular Biology International, 2012 This special issue entitled “DNA in 3R: Repair, Replication, and Recombination” is dedicated to biological processes that preserve the integrity of our genome. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to clinical scientists.
Coin, Frédéric +3 more
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