Results 41 to 50 of about 8,966 (220)
Homologous pairing activities of two rice RAD51 proteins, RAD51A1 and RAD51A2. [PDF]
PLoS ONE, 2013 In higher eukaryotes, RAD51 functions as an essential protein in homologous recombination and recombinational repair of DNA double strand breaks. During these processes, RAD51 catalyzes homologous pairing between single-stranded DNA and double-stranded ...
Yuichi Morozumi +8 more
doaj +1 more source
mBio, 2023 Staphylococcus aureus is a major human pathogen that causes a variety of illnesses, ranging from minor skin and soft tissue infections to more severe systemic infections. Although the primary host immune response can typically clear bacterial infections,
Kelly E. Hurley +5 more
doaj +1 more source
The helicase DinG responds to stress due to DNA double strand breaks. [PDF]
PLoS ONE, 2017 Neisseria meningitidis (Nm) is a Gram-negative nasopharyngeal commensal that can cause septicaemia and meningitis. The neisserial DNA damage-inducible protein DinG is a helicase related to the mammalian helicases XPD and FANCJ.
Stephan A Frye +8 more
doaj +1 more source
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]
, 2013 Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy +9 more
core +1 more source
Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase. [PDF]
PLoS Pathogens, 2009 Persistent infection by pathogenic organisms requires effective strategies for the defense of these organisms against the host immune response. A common strategy employed by many pathogens to escape immune recognition and clearance is to continually vary
Ashley R Dresser +2 more
doaj +1 more source
Two time constants for the binding of proteins to DNA from micromechanical data [PDF]
, 2000 Recent experimental advances allow the direct measurement of the force/extension behavior for DNA in the presence of strongly binding proteins. Such experiments reveal information about the cooperative mechanism of protein binding.
Turner, Matthew S., Matthew S. Turner
core +1 more source
, 2002 Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT). Although disease relapse is the major cause of death after a melphalan-conditioned autograft, the mechanism ...
Mahendra, P +11 more
core +1 more source
Several pathways of hydrogen peroxide action that damage the E. coli genome
Genetics and Molecular Biology, 2004 Hydrogen peroxide is an important reactive oxygen species (ROS) that arises either during the aerobic respiration process or as a by-product of water radiolysis after exposure to ionizing radiation.
Nasser Ribeiro Asad +5 more
doaj +1 more source
, 2005 Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström +16 more
core +1 more source
RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
Photochemistry and Photobiology, EarlyView.UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source