Results 61 to 70 of about 8,966 (220)

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

Biochemical characterization of the nuclease StoNurA from the hyperthermophilic archaeon Sulfolobus tokodaii

Anais da Academia Brasileira de Ciências
The DNA nuclease gene ST2109 has been cloned from the hyperthermophilic archaeon Sulfolobus tokodaii and expressed in Escherichia coli. The recombinant protein StoNurA has been purified to homogeneity by affinity chromatography and gel filtration ...
Tao Wei, Kunpeng Yang, Jie Zang, Duobin Mao   +3 more
doaj   +1 more source

Subunit interface residues F129 and H294 of human RAD51 are essential for recombinase function. [PDF]

PLoS ONE, 2011
RAD51 mediated homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs) is essential to maintain genomic integrity. RAD51 forms a nucleoprotein filament (NPF) that catalyzes the fundamental homologous pairing and strand exchange ...
Ravindra Amunugama, Richard Fishel
doaj   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Isolation and characterization of "Arabidopsis" mutants with altered homologous recombination levels : a new function for an INO80 SWI/SNF ATPase [PDF]

, 2006
Homologous recombination (HR) in eukaryotic organisms serves a dual role in providing genetic flexibility by creating novel sequence assortments upon meiosis and in maintaining genome integrity through DNA repair in somatic tissues.
Fritsch, Olivier
core   +1 more source

Deletion of the primase-polymerases encoding gene, located in a mobile element in Thermus thermophilus HB27, leads to loss of function mutation of addAB genes

Frontiers in Microbiology, 2022
DNA primase-polymerases (Ppol) have been shown to play active roles in DNA repair and damage tolerance, both in prokaryotes and eukaryotes. The ancestral thermophilic bacterium Thermus thermophilus strain HB27 encodes a Ppol protein among the genes ...
Carlos Verdú, Patricia Pérez-Arnaiz, Ana Peropadre, José Berenguer, Mario Mencía   +4 more
doaj   +1 more source

Silene, a versatile model system: from sex and genome evolution to ecology and speciation

New Phytologist, Volume 250, Issue 6, Page 3613-3630, June 2026.
Summary Fundamental and applied research in evolutionary biology benefits from the use of model systems in which approaches from disparate disciplines can be integrated. Here, we review recent progress in evolutionary research on the long‐standing model system Silene, a large genus with a well‐resolved phylogeny and newly available, expanded genomic ...
Sophie Karrenberg, Václav Bačovský, Andrea E. Berardi, Isabelle De Cauwer, Tatiana Giraud, Fanny E. Hartmann, Roman Hobza, Vojtěch Hudzieczek, Gabriel A.B. Marais, Jenna R. Miladin, Bengt Oxelman, Alexander S.T. Papadopulos, Daniel B. Sloan, Janet C. Steven, Helena Štorchová, Pascal Touzet, Fabienne Van Rossum   +16 more
wiley   +1 more source

The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.

PLoS Genetics, 2021
The RarA protein, homologous to human WRNIP1 and yeast MgsA, is a AAA+ ATPase and one of the most highly conserved DNA repair proteins. With an apparent role in the repair of stalled or collapsed replication forks, the molecular function of this protein ...
Kanika Jain, Elizabeth A Wood, Michael M Cox   +2 more
doaj   +1 more source

How Salmonella Works Under Osmotic and Desiccation Stresses

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Salmonella remains one of the leading threats in foods with reduced water activity, where it can survive for long periods and cause outbreaks. Its persistence stems from a wide array of adaptive strategies shaped by the selective pressures imposed by low‐moisture foods.
Mayara Messias Oliveira, Dionisio P. Amorim‐Neto, Anderson S. Sant'Ana   +2 more
wiley   +1 more source

Recombination suppression in plant adaptation and speciation

New Phytologist, Volume 250, Issue 4, Page 2061-2077, May 2026.
Summary Recombination suppression is increasingly recognized as an important facilitator of genomic divergence and speciation, especially under ongoing gene flow. In plants, however, the broader evolutionary consequences and the mechanisms by which recombination suppression arises and spreads are still incompletely understood, reflecting the inherent ...
Xu Zhang, Yisi Hu, Kaichi Huang, Stephen I. Wright, Loren H. Rieseberg   +4 more
wiley   +1 more source