Results 81 to 90 of about 8,966 (220)
MutSβ Stimulates Holliday Junction Resolution by the SMX Complex
Cell Reports, 2020 Summary: MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of the ...
Sarah J. Young +7 more
doaj +1 more source
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Advanced Science, Volume 13, Issue 12, 27 February 2026.Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source
Cancer Science, Volume 117, Issue 2, Page 429-444, February 2026.The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi +5 more
wiley +1 more source
Homologous recombination in DNA repair and DNA damage tolerance [PDF]
Cell Research, 2008 Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition, recombination provides critical support for DNA replication in the recovery of stalled or broken replication forks, contributing to tolerance of DNA damage.
Xuan, Li, Wolf-Dietrich, Heyer
openaire +2 more sources
Use of a unique reporter cassette to examine 5´ to 3´ resection at a site specific DNA double-strand break during meiosis [PDF]
, 2006 Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand breaks (DSBs), which are created by Spoil protein.
Bishop-Bailey, Anna
core
PLoS Genetics, 2019 Faithful replication and repair of DNA lesions ensure genome maintenance. During replication in eukaryotic cells, DNA is unwound by the CMG helicase complex, which is composed of three major components: the Cdc45 protein, Mcm2-7, and the GINS complex ...
Malgorzata Jedrychowska +6 more
doaj +1 more source
Genomic Perspective on Heterogeneity of Organs and Body Aging
Aging Cell, Volume 25, Issue 1, January 2026.Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi +2 more
wiley +1 more source
Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes [PDF]
Microbial Cell, 2019 Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single-cell level.
Klein, HL +25 more
openaire +6 more sources
, 2012 Pancreatic cancer is an aggressive solid malignancy with poor response to therapy and the subsequent dismal survival rate has remained a hallmark of this disease.
Nagathihalli, Nagaraj S. +3 more
core +1 more source
Structural basis for DNA 5´-end resection by RecJ
eLife, 2016 The resection of DNA strand with a 5´ end at double-strand breaks is an essential step in recombinational DNA repair. RecJ, a member of DHH family proteins, is the only 5´ nuclease involved in the RecF recombination pathway.
Kaiying Cheng +6 more
doaj +1 more source