Results 11 to 20 of about 8,966 (220)

The cohesin-like RecN protein stimulates RecA-mediated recombinational repair of DNA double-strand breaks

Nature Communications, 2017
RecN is a cohesin-like molecule involved in the bacterial response to DNA double-strand breaks. Here the authors provide evidence that RecN stimulates the DNA strand invasion step of RecA-mediated recombination.
Lee A. Uranga, Emigdio D. Reyes, Praveen L. Patidar, Lindsay N. Redman, Shelley L. Lusetti   +4 more
doaj   +2 more sources

An Overview of the Molecular Mechanisms of Recombinational DNA Repair. [PDF]

Cold Spring Harb Perspect Biol, 2015
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for genomic integrity. It is a template-directed process that uses a second chromosomal copy (sister, daughter, or homolog) to ensure proper repair of broken chromosomes.
Kowalczykowski SC.
europepmc   +2 more sources

Functional characterization of excision repair and RecA-dependent recombinational DNA repair in Campylobacter jejuni. [PDF]

J Bacteriol, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Gaasbeek EJ, van der Wal FJ, van Putten JP, de Boer P, van der Graaf-van Bloois L, de Boer AG, Vermaning BJ, Wagenaar JA.   +7 more
europepmc   +2 more sources

DNA repair, recombination, and damage signaling [PDF]

Genetics, 2021
AbstractDNA must be accurately copied and propagated from one cell division to the next, and from one generation to the next. To ensure the faithful transmission of the genome, a plethora of distinct as well as overlapping DNA repair and recombination pathways have evolved.
Gartner, Anton, Engebrecht, JoAnne
openaire   +4 more sources

Structural basis for the coiled-coil architecture of human CtIP

Open Biology, 2021
The DNA repair factor CtIP has a critical function in double-strand break (DSB) repair by homologous recombination, promoting the assembly of the repair apparatus at DNA ends and participating in DNA-end resection.
C. R. Morton, N. J. Rzechorzek, J. D. Maman, M. Kuramochi, H. Sekiguchi, R. Rambo, Y. C. Sasaki, O. R. Davies, L. Pellegrini   +8 more
doaj   +1 more source

Stabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair. [PDF]

EMBO J, 2017
Cells are constantly threatened by multiple sources of genotoxic stress that cause DNA damage. To maintain genome integrity, cells have developed a coordinated signalling network called DNA damage response (DDR).
Villoria MT, Ramos F, Dueñas E, Faull P, Cutillas PR, Clemente-Blanco A.   +5 more
europepmc   +2 more sources

The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete

Frontiers in Microbiology, 2022
The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE.
Mildred Castellanos, Theodore B. Verhey, Madeleine Goldstein, George Chaconas, George Chaconas   +4 more
doaj   +1 more source

DNA Metabolism in Balance: Rapid Loss of a RecA-Based Hyperrec Phenotype. [PDF]

PLoS ONE, 2016
The RecA recombinase of Escherichia coli has not evolved to optimally promote DNA pairing and strand exchange, the key processes of recombinational DNA repair.
Irina V Bakhlanova, Alexandra V Dudkina, Elizabeth A Wood, Vladislav A Lanzov, Michael M Cox, Dmitry M Baitin   +5 more
doaj   +1 more source

Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51

Nature Communications, 2020
Rad51 drives DNA strand exchange, the central reaction in recombinational DNA repair. Two sites of Rad51 are responsible for DNA binding, but the function of these sites has proven elusive.
Kentaro Ito, Yasuto Murayama, Yumiko Kurokawa, Shuji Kanamaru, Yuichi Kokabu, Takahisa Maki, Tsutomu Mikawa, Bilge Argunhan, Hideo Tsubouchi, Mitsunori Ikeguchi, Masayuki Takahashi, Hiroshi Iwasaki   +11 more
doaj   +1 more source

Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation. [PDF]

PLoS ONE, 2011
At any time, each cell of the protozoan parasite Trypanosoma brucei expresses a single species of its major antigenic protein, the variant surface glycoprotein (VSG), from a repertoire of >2,000 VSG genes and pseudogenes.
Hee-Sook Kim, George A M Cross
doaj   +1 more source