Advanced Science, EarlyView.A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng +9 more
wiley +1 more source
Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE) [PDF]
Reconstructed Human Epidermis (RHE) is an artificial epidermis made in such a way that it resembles human skin, and can be used for the identification of irritant chemicals, especially for cosmetic and topical medicinal products. Currently the new RHE
Eka Rusmawati, Eka +5 more
core
Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface
Advanced Science, EarlyView.This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang +11 more
wiley +1 more source
The effects of targeted delivery of hydrocortisone and betamethasone 17 valerate encapsulated in multilamellar liposomes using reconstructed human epidermis with keratinocytes mimicking atopic dermatitis [PDF]
Antoine Bernasqué +6 more
openalex +1 more source
Dynamic Supercooled Crystal–Gels for Ultrafast, Reversible Mechanical Adaptative Materials
Advanced Science, EarlyView.A dynamic supercooled crystal–gel mimics starfish tissue by storing non‐equilibrium energy in a metastable liquid. A gentle touch triggers templated crystallization, producing a 2596‐fold stiffness increase with negligible volume change. The lattice disintegrates reversibly under humidity or warmth.
Yuesong Lv +9 more
wiley +1 more source
928 Hyphae production by malassezia furfur yeasts on reconstructed human epidermis [PDF]
, 2023 Bastien Tirtiaux +4 more
openalex +1 more source
TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer
Advanced Science, EarlyView.DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia +15 more
wiley +1 more source
Exposure to the antimicrobial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis (dataset). [PDF]
, 2023 openalex +1 more source
Hierarchical Organization of Biomaterials in the Formation of Photonic Nanostructures
Advanced Science, EarlyView.Natural organisms create vibrant structural colors through precisely organized nanostructures formed under mild biological conditions. This review explores how cellulose, chitin, corneous beta‐protein, and melanin form complex nanostructures across molecular, mesoscale, and tissue levels.
Sangyeop Kim +5 more
wiley +1 more source
Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis [PDF]
Irini Magdelina Dijkhoff +6 more
openalex +1 more source