Results 141 to 150 of about 9,223,247 (288)

A modified protocol for studying filaggrin degradation using a reconstructed human epidermis model under low and high humidity [PDF]

, 2023
Qilong Chen, Ning Wei, Yina Lu
openalex   +1 more source

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Identification of Keratinocyte Cytoprotectants against Toxicity by the Multikinase Inhibitor Sorafenib Using Drug Repositioning

JID Innovations
Hand–foot skin reaction is the most common adverse event of multikinase inhibitors, such as sorafenib. Although hand–foot skin reaction is not life threatening, severe cases impair quality of life because of pain and reduced activities of daily living ...
Yayoi Kamata, Rui Kato, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Jun Utsumi, Takahide Kaneko, Yasushi Suga, Kenji Takamori   +8 more
doaj   +1 more source

Performance Standards for the Assessment of Proposed Similar or Modified in Vitro Phototoxicity: Reconstructed Human Epidermis (RhE) Test Methods for Testing of Topically Applied Substances, as described in Test Guideline 498 [PDF]

, 2023
OECD
openalex   +1 more source

326 Modeling dermatophytosis in reconstructed human epidermis [PDF]

Journal of Investigative Dermatology, 2016
E. Faway, L. Cambier, C. Lambert de Rouvroit, B. Mignon, Y. Poumay   +4 more
openaire   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Stage‐Adaptive Bilayer Hydrogel Coordinates Photodynamic Antibacterial Therapy with Engineered Extracellular Vesicle–Mediated Immunomodulation in Infected Diabetic Wounds

Advanced Science, EarlyView.
Early photodynamic infection control and subsequent immunoregulatory repair are spatially separated within a stage‐adaptive bilayer hydrogel. Chlorin e6 is incorporated into the wound‐contacting layer to provide light‐triggered bactericidal therapy, whereas the upper layer regulates excessive reactive oxygen species before releasing microRNA‐146a ...
Gaofei Zhang, Boheng Zhu, Shihao Deng, Pan Du, Jun Pu, Xin Wang, Shuqian Dou, Yifei Wang, Wenjun Liu   +8 more
wiley   +1 more source