Results 121 to 130 of about 9,223,247 (288)

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Nanoindentation-Informed Skin Bilayer Modeling Links Stiffness Heterogeneity to Curvature Localization Under Glycation and Carbonyl Stress

Cosmetics
Glycation and reactive carbonyl stress are protein-modifying processes associated with skin aging, but how they alter local tissue mechanics and deformation-prone behavior remains unclear.
Yiwen Li, Feng Cao, Qianwen Fan, Xi Yang, Yulan Qu, Xiangjun Gong, Jian Cao, Guangwen He, Robert Maidhof, Huanjun Zhou   +9 more
doaj   +1 more source

Characterisation of keratinocyte-derived epidermal signals in the initiation of contact hypersensitivity to chemicals [PDF]

, 2015
Contact hypersensitivity reactions result from an adaptive immune response following topical exposure to chemical allergen. The initiation of this response requires the production of an inflammatory micro-environment, however the contribution of ...
Summerfield, VL
core  

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE) [PDF]

, 2018
Reconstructed Human Epidermis (RHE) is an artificial epidermis made in such a way that it resembles human skin, and can be used for the identification of irritant chemicals, especially for cosmetic and topical medicinal products. Currently the new RHE is produced by European and American countries, whose skin physiology is very different from Indonesia.
Herlina B. Setijanti, Eka Rusmawati, Rahmi Fitria, Tuty Erlina, Rina Adriany, null Murtiningsih   +5 more
openaire   +1 more source

Reconstructed human epidermis for skin absorption testing: Results of the German prevalidation study

, 2006
Exposure to chemicals absorbed by the skin can threaten human health. In order to standardise the predictive testing of percutaneous absorption for regulatory purposes, the OECD adopted guideline 428, which describes methods for assessing absorption by ...
Kamp, H., Schmidt, E., Kietzmann, M., Kaca, M., Schroder, K. R., Gamer, A., Korting, H. C., Bock, U., Haltner-Ukomadu, E., Schafer, U., Spielmann, H., Haberland, A., Krachter, H. U., Vuia, A., Liebsch, M., Netzlaff, F., Niedorf, F., Mehling, A., Schäfer-Korting, M., Lehr, C. M., Rubbelke, M. K., Schreiber, S.   +21 more
core  

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

Barrier Ëunction in Reconstructed Epidermis and Its Resembiance to Native Human Skin

, 2001
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin.
Ponec, M., Bouwstra, J., Mommaas, M., BoeIsma, E., GPilgram, G., Koerten, H., Gibbs, S.   +6 more
core  

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source