Results 101 to 110 of about 7,690,139 (265)

Methyl-β-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis [PDF]

, 2016
Reconstructed human epidermis (RHE) mimic normal human in vivo epidermis in terms of histology, distribution of differentiation markers, and barrier functionality (1).
Nikkels, Arjen F, Mound, Abdallah, De Vuyst, Evelyne, Chrétien, Aline, Jérémy Malaisse, Yves Poumay, Malaisse, Jérémy, Évelyne De Vuyst, Abdallah Mound, Poumay, Yves, Séverine Giltaire, Lambert de Rouvroit, Catherine, Aline Chrétien, Lambert de Rouvroit, Catherine; id_orcid, NIKKELS, Arjen, Arjen F. Nikkels, Michel Salmon, Giltaire, Séverine, Bourtembourg, Maureen, Catherine Lambert de Rouvroit, Maureen Bourtembourg, Salmon, Michel, Poumay, Yves; id_orcid   +22 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Wearable Electro‐Thermal Haptic Stimulator Driven by a Self‐Powered Tactile Sensor for Realistic Stimulus Replication

Advanced Science, EarlyView.
We present a stimulus‐replicating system combining a tactile sensor with a wearable Peltier thermotactile module and concentric electrotactile electrode. Signals encoding pressure and temperature drive the stimulators to reproduce mechano‐thermal cues on the skin. AlN/PDMS encapsulation and SA/LA PSA ensure mechanical compliance and thermal efficiency.
Ey‐In Lee, Chae‐Young Kang, Kyuhyun Hwang, Jongbaeg Kim, Jin‐Woo Park   +4 more
wiley   +1 more source

Esterase Activity and Intracellular Localization in Reconstructed Human Epidermal Cultured Skin Models [PDF]

, 2014
Background : Reconstructed human epidermal culture skin models have been developed for cosmetic and pharmaceutical research. Objective : This study evaluated the total and carboxyl esterase activities (i.e., Km and Vmax, respectively) and localization in
橋本, フミ惠, 徳留, 嘉寛, 片柳, 美姿   +2 more
core   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE) [PDF]

, 2018
Reconstructed Human Epidermis (RHE) is an artificial epidermis made in such a way that it resembles human skin, and can be used for the identification of irritant chemicals, especially for cosmetic and topical medicinal products. Currently the new RHE is produced by European and American countries, whose skin physiology is very different from Indonesia.
Herlina B. Setijanti, Eka Rusmawati, Rahmi Fitria, Tuty Erlina, Rina Adriany, null Murtiningsih   +5 more
openaire   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Cortisol synthesis by primary human keratinocytes [PDF]

, 2009
PhDCortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported.
Hannen, Rosalind Francesca
core   +2 more sources

Protein-reconstructed artificial epidermis for transdermal permeation testing

Transdermal permeation testing is important in assessing therapeutic molecules in applications such as cosmetics and pharmaceuticals. Progress in these fields has been hindered by the lack of inexpensive skin models that closely mimic human skin ...
Fan, Hangming
core   +1 more source

Use of human reconstructed epidermis to analyze the regulation of -defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS

, 2003
International audienceDefensins have been identified as key elements of innate immunity against microbial infections. In the present study, human beta-defensin-2 (hBD-2) mRNA and peptide expression were evaluated by RT-PCR and Western blotting in normal ...
Goidin, D., Schmitt, D., Staquet, M-J., Chadebech, P., Jacquet, C., Viac, J.   +5 more
core   +1 more source