Results 101 to 110 of about 9,223,247 (288)

Skin Concentrations of Topically Applied Substances in Reconstructed Human Epidermis (RHE) Compared with Human Skin Using in vivo Confocal Raman Microscopy

CHIMIA, 2015
Detailed knowledge about the skin concentration of topically applied substances is important to understand their local pharmacological activity. In particular since in vitro models of reconstructed human epidermis are increasingly used as models
Franziska D. Fleischli, Fabienne Morf, Christian Adlhart   +2 more
doaj   +1 more source

Model For Human Skin Reconstructed In Vitro Composed Of Associated Dermis And Epidermis.

, 2015
The technique of obtaining human skin with dermis and epidermis reconstructed from cells isolated from patients can enable autologous skin grafting on patients with few donor sites. It also enables in vitro trials on chemicals and drugs. The objective of
Souto, Luís Ricardo Martinhão, Rehder, Jussara, Vassallo, José, Cintra, Maria Letícia, Kraemer, Maria Helena Stangler, Puzzi, Maria Beatriz   +5 more
core  

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Skin toxicity of lead iodide perovskites evaluated using human skin cell and tissue models [PDF]

Materials Advances
Perovskite solar cells based on organic–inorganic lead halide materials are advancing toward practical implementation, yet their potential risks to human health remain insufficiently understood, particularly in relation to direct skin contact during ...
Masafumi Koremura, Nao Saito, Masashi Ikegami, Tsutomu Miyasaka, Kaoru Yoshida   +4 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

General scheme of the experiment with RHE (Reconstructed Human Epidermis) model and lupeol derivates (PBS–phosphate buffer, i-PrOH–isopropanol, RT–room temperature, MTT—3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, OD–optical density).

, 2019
General scheme of the experiment with RHE (Reconstructed Human Epidermis) model and lupeol derivates (PBS–phosphate buffer, i-PrOH–isopropanol, RT–room temperature, MTT—3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, OD–optical density).
Maciej Szaleniec (2301652), Jan Ogonowski (2105743), Barbara Miroslaw (694312), Elzbieta Sikora (6524714), Monika Pasikowska-Piwko (6524720), Irena Eris (6524723), Magdalena Malinowska (6524711), Agnieszka M. Wojtkiewicz (6524717)   +7 more
core   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source

Analysis of the mechanical properties of in vitro reconstructed epidermis: preliminary results

, 1999
Human epidermis can be reconstructed in vitro and is currently used in autografts for the treatment of severe, extensive burns and pigmentation disorders. However, there are neither international standards nor a common nomenclature for engineered tissues.
Chistolini P, DE LUCA, Michele, De Angelis G, Ruspantini I., PELLEGRINI, Graziella   +4 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Advancing preclinical research with reconstructed in vitro skin models mimicking non-healing wounds

International Journal of Pharmaceutics: X
Chronic skin wounds remain a significant therapeutic challenge worldwide, primarily due to persistent inflammation, impaired function of fibroblasts and keratinocytes, defective angiogenesis, and the presence of complex polymicrobial biofilms ...
Regina Gomes Daré, Luciana B. Lopes, Alke Petri-Fink, Barbara Rothen-Rutishauser   +3 more
doaj   +1 more source