Results 111 to 120 of about 7,690,139 (265)

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial

Biomolecules
Polymethoxyflavones from Kaempferia parviflora rhizomes have been shown to effectively combat aging in skin cells and tissues by inhibiting senescence, reducing oxidative stress, and enhancing skin structure and function.
Wannita Klinngam, Phetploy Rungkamoltip, Ratjika Wongwanakul, Jaruwan Joothamongkhon, Sakkarin Du-a-man, Mattaka Khongkow, Udom Asawapirom, Tawin Iempridee, Uracha Ruktanonchai   +8 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Invasion of Human Epidermis by Malassezia furfur is Strain Dependent

Data collected in the attempt to study hyphal growth by Malassezia furfur on a Reconstructed Human Epidermis ...
Namur Research Institute for Life Sciences, Tirtiaux, Bastien, URPHYM, University of Namur, Poumay, Yves; id_orcid   +4 more
core   +2 more sources

Soft Hypoxia‐Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed‐Loop Therapeutics of Chronic Wounds

Advanced Science, EarlyView.
Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao, Gang Song, Pingqiang Cai, Zheng Li, Zhiyuan Liu, Dianpeng Qi, Ting Wang, Lianhui Wang   +16 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

Virulence, 2018
Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous ...
Magali Garcia, Eric Morello, Julien Garnier, Christine Barrault, Martine Garnier, Christophe Burucoa, Jean-Claude Lecron, Mustapha Si-Tahar, François-Xavier Bernard, Charles Bodet   +9 more
doaj   +1 more source

A Comprehensive Comparison of Tissue Processing Methods for High-Quality MALDI Imaging of Lipids in Reconstructed Human Epidermis. [PDF]

J Am Soc Mass Spectrom, 2023
Feucherolles M, Le W, Bour J, Jacques C, Duplan H, Frache G.   +5 more
europepmc   +1 more source

Visualization of diffusion pathways across the stratum corneum of native and in-vitro-reconstructed epidermis by confocal laser scanning microscopy.

, 1995
Confocal laser scanning microscopy is a technique that permits the direct visualization in unfixed material of diffusion pathways and the cellular distribution of fluorescent markers after topical applications. This approach, in which the tissue specimen
SCHRIJVERS AH, HOOGSTRAATE AJ, BODDÉ HE, BIALIK W, PONEC M., SIMONETTI, Oriana, KEMPENAAR JA   +6 more
core   +1 more source