Results 221 to 230 of about 7,690,139 (265)

Skin innervation and its <i>in vitro</i> modeling. [PDF]

Front Cell Neurosci
Genin É, Guerber L, Aymard E, Leng J, Amédée J, Desmoulière A, Berthod F.   +6 more
europepmc   +1 more source

Spatiotemporal fluorescence imaging of microRNA activity in 3-D models of human epidermis reveals contribution of the Notch pathway in the regulation of miR-30a in aging skin. [PDF]

JID Innov
Gonzalez Torres A, Chevalier FP, Aquino R, Aimard M, Baril P, Lamartine J.   +5 more
europepmc   +1 more source

Barrier Function in Reconstructed Epidermis and Its Resemblance to Native Human Skin

Skin Pharmacology and Physiology, 2001
One of the prerequisites for the use of human skin equivalents for scientific and screening purposes is that their barrier function is similar to that of native skin. Using human epidermis reconstructed on de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged from ...
Ponec, M., Gibbs, S., Pilgram, G., Boelsma, E., Koerten, H., Bouwstra, J., Mommaas, M.   +6 more
core   +9 more sources

Reconstructed human epidermis: A model to study the barrier function

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2005
The use of in vitro reconstructed human epidermis (RHE) by the cosmetic and pharmaceutical industries is increasing because of its similar physiological mechanisms to native human skin. With the advent of ethic laws on animal experimentation, RHE provides an helpful alternative for the test of formulations.
Barbotteau, Y., Gontier, E., Barbaret, P., Cappadoro, M., De Wever, B., Cappadoro, M., Habchi, C., Incerti, S., Mavon, A., Moretto, P., Pouthier, T., Smith, Richard, Ynsa, M.D   +12 more
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A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies

Archives of Dermatological Research, 2004
The preparation of a reconstructed human epidermis is described with examples of its utilization in in vitro studies. The model was obtained by culturing normal human keratinocytes at high cell density for 14 days in serum-free and high calcium (1.5 m M) medium on an inert polycarbonate filter at the air-liquid interface.
Yves Poumay
exaly   +4 more sources

Impaired desquamation in the in vitro reconstructed human epidermis

Cell and Tissue Research, 1996
A fully differentiated epidermis generated in vitro by culturing normal human keratinocytes at the air-liquid interface shares many similarities with native tissue. However, in contrast to native epidermis, its stratum corneum consists of a larger number of compactly packed corneocyte layers, indicating that the processes involved in corneocyte ...
Aat Mulder, Jana Vičanová, Maria Ponec   +2 more
exaly   +3 more sources

Reconstructed human epidermis for in vitro studies on atopic dermatitis: A review

Journal of Dermatological Science, 2018
Atopic dermatitis (AD) is a chronic inflammatory skin disease causing a strong impact on quality of life. Its pathophysiology is the result of complex interactions involving immunological, genetic and environmental factors. Although there are several published in vitro three-dimensional models mimicking AD, none of them have taken all these ...
Laurent Misery, Flavien Huet, Christelle le Gall-Ianotto   +2 more
exaly   +5 more sources

Characterization and applications of human epidermis reconstructed in vitro on de-epidermized derma

Il Farmaco, 1998
In recent years in vitro models have been developed to avoid the use of animals in cutaneous toxicological studies. Submerged human keratinocyte cultures in vitro could be so far employed as an alternative to animal testing and a good correlation between skin irritation and cytotoxicity has been demonstrated.
PARNIGOTTO, PIER PAOLO, BERNUZZO S, BRUNO P, CONCONI, MARIA TERESA, MONTESI F.   +4 more
openaire   +4 more sources

Reconstructed epidermis versus human and animal skin in skin absorption studies

Toxicology in Vitro, 2005
European chemical policy in general and the REACH initiative in particular will increase the number of chemical substances submitted to toxicological evaluation by several orders of magnitude compared to the current status. To limit animal exposure the resulting enormous increase in testing, however, asks for validated in vitro test systems.
Helena Kandarova, M Liebsch, H C Korting   +2 more
exaly   +3 more sources

Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study

ATLA Alternatives To Laboratory Animals, 2006
Exposure to chemicals absorbed by the skin can threaten human health. In order to standardise the predictive testing of percutaneous absorption for regulatory purposes, the OECD adopted guideline 428, which describes methods for assessing absorption by ...
Monika Schäfer-Korting, Claus-Michael Lehr, Horst Spielmann   +2 more
exaly   +1 more source