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Selective Induction of Interleukin-12 in Reconstructed Human Epidermis by Chemical Allergens
Alternatives to Laboratory Animals, 1999Keratinocytes play an important role in skin inflammatory and immunological reactions through the release of cytokines and response to them. These cells have been shown to direct T-cell priming by producing cytokines such as interleukin (IL)-10 and IL-12.
E. Corsini +5 more
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Reconstructed Human Epidermis: A Model to Study in vitro the Barrier Function of the Skin
Skin Pharmacology, 2009In previous studies, we have shown that architecture and differentiation of human epidermis reconstructed by culturing dissociated keratinocytes on deepidermized dermis at the air-liquid interface resembles very much those of epidermis in vivo. The various types of epidermal layers are present with the appropriate differentiation markers, such as the ...
M, Régnier +3 more
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Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes
European Journal of Pharmaceutics and Biopharmaceutics, 2017Extrinsic (photo) aging accelerates chronologically aging in the skin due to cumulative UV irradiation. Despite recent insights into the molecular mechanisms of fibroblast aging, age-related changes of the skin barrier function have been understudied.
Lilian Julia, Löwenau +8 more
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Malassezia interaction with a reconstructed human epidermis: Keratinocyte immune response
Mycoses, 2019SummaryThe immediate immune response developed by the keratinocytes against Malassezia yeasts has been addressed yielding conflicting results. This study aims the assessment of cytokines and antimicrobial peptides gene expression elicited by M. sympodialis and M. furfur once in contact with a reconstructed human epidermis.
Ana F. Pedrosa +5 more
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Comparison of surface free energy between reconstructed human epidermis and in situ human skin
Skin Research and Technology, 2000Background/aims: The objectives of this study were to characterise the Episkin® model of reconstructed epidermis histologically and energetic, and to compare the results with the data obtained by Mavon (9, 10) on different areas of skin on the human body and on different skin types.Methods: Histologically, the two skin systems studied were stained ...
Lerebour, G. +3 more
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Optimizing photopollution assessment: Insights from a reconstructed human epidermis model
International Journal of PharmaceuticsThe Reconstructed Human Epidermis (RHE) model offers a significant in vitro alternative to animal testing for cosmetic safety and efficacy. This physiologically relevant system evaluates skin responses, meeting ethical, scientific, and regulatory demands. It is particularly useful for studying ultraviolet radiation (UV) and air pollution, key stressors
Maria da Graça Landim Bravo +8 more
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Reconstruction of human skin epidermis in vitro
1996Abstract Since the pioneering work of Rheinwald and Green in 1975 (1, 2) for establishing keratinocytes in culture, numerous advances have been made in the reconstruction of human epidermis in vitro. The more recent techniques are based on the reconstruction of a substrate resembling dermis on which keratinocytes of different sources ...
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Preparation and characterization of Reconstructed Human Epidermis (RHE)
Toxicology Letters, 2015F. Rami +7 more
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