Results 231 to 240 of about 7,690,139 (265)

Barrier Function of Human Skin and Human Reconstructed Epidermis

Journal of Pharmaceutical Sciences, 1993
The present study compares the stratum corneum of human skin and human reconstructed epidermis by histological examination as well as by estimation of water permeability. Measurement of the percutaneous absorption of benzoic acid, testosterone, and hydrocortisone revealed that under the same experimental conditions the reconstructed epidermis on de ...
M, Regnier, D, Caron, U, Reichert, H, Schaefer   +3 more
openaire   +2 more sources

Interaction of liposomes with human epidermis reconstructed in vitro

British Journal of Dermatology, 2006
Upon topical application of liposomes of the large unilamellar vesicle type to human epidermis reconstructed in vitro, there is a dose-dependent alteration of the morphology of both the stratum corneum and the living part of the epidermis. In particular, shrunken lipid droplets are found between corneocytes and keratinocytes.
H C, Korting, W, Stolz, M H, Schmid, G, Maierhofer   +3 more
openaire   +2 more sources

Cx26 Affects the in Vitro Reconstruction of Human Epidermis

Cell Communication & Adhesion, 2001
To study the function of connexins in human keratinocytes, we have used a three-dimensional culture system, in which a tissue is reconstructed using cells from the outer root sheet of hair follicles. This tissue reproduces in vitro the histological organisation of human epidermis in situ and the normal distribution of several keratinocyte markers ...
Wiszniewski L, Salomon D, Meda P
openaire   +3 more sources

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

ATLA Alternatives To Laboratory Animals, 2008
A formal validation study was performed, in order to investigate whether the commercially available reconstructed human epidermis (RHE) models, EPISKIN®, EpiDermT and SkinEthic®, are suitable for in vitro skin absorption testing.
Monika Schäfer-Korting, Claus-Michael Lehr, Horst Spielmann   +2 more
exaly   +1 more source

Establishment and characterization of a reconstructed Chinese human epidermis model

International Journal of Cosmetic Science, 2015
SynopsisObjectivesIn vitro reconstructed human epidermis is a powerful tool for both basic research and industrial applications in dermatology, pharmacology and the cosmetic field.MethodsBy growing keratinocytes of Chinese origin on a collagen matrix after a submerged culture followed by an air–liquid interface culture, an in vitro reconstructed ...
J, Qiu, L, Zhong, M, Zhou, D, Chen, X, Huang, J, Chen, M, Chen, H, Ni, Z, Cai   +8 more
openaire   +2 more sources

Fibroblasts and ascorbate regulate epidermalization in reconstructed human epidermis

Journal of Dermatological Science, 2002
Skin equivalent model provides a new investigating system to study the role of extracellular matrix and dermal factors such as collagen, basement membrane components and fibroblasts (Fb) which contribute to cell-cell and cell-matrix interactions. Although basement membrane factors is known to play an important role in epidermal differentiation and ...
Suk, Wha Kim, Il-Whan, Lee, Hyun-Joo, Cho, Kwang-Hyun, Cho, Kyu, Han Kim, Jin-Ho, Chung, Peter I, Song, Kyoung, Chan Park   +7 more
openaire   +2 more sources

Nitroglycerin and Sucrose Permeability as Quality Markers for Reconstructed Human Epidermis

Skin Pharmacology, 2009
In order to evaluate the epidermal permeability barrier of in vitro reconstructed epidermis, the penetration of nitroglycerin (NG) and sucrose were measured across human keratinocytes cultured at the air-liquid interface, using de-epidermized dermis (DED) as a substrate.
M, Ponec, P J, Wauben-Penris, A, Burger, J, Kempenaar, H E, Boddé   +4 more
openaire   +2 more sources

The Reconstructed Human Epidermis Models in Fundamental Research

2009
Large skin trauma allows pathogens to invade, and causes water, electrolyte and protein loss, inducing adverse events often incompatible with sustained life if the wound is not rapidly covered and the lost tissue replaced. This last point is often critical in wound management because of the poor availability of skin samples.
Coquette, Alain, Poumay, Yves
openaire   +2 more sources

Reconstructed human epidermis composed of keratinocytes, melanocytes and Langerhans cells

Medical & Biological Engineering & Computing, 1998
In addition to their basic biological interest, models of reconstructed epidermis provide useful tools for in vitro assessment of the toxicology and efficacy of new chemicals and drugs. The fact that the majority of these in vitro models are composed only of keratinocytes has excluded their use in the fields of skin pigmentation and immunology.
M, Régnier, A, Patwardhan, A, Scheynius, R, Schmidt   +3 more
openaire   +2 more sources

Malassezia colonisation on a reconstructed human epidermis: Imaging studies

Mycoses, 2019
Summary Background Biofilm formation represents a major microbial virulence attribute especially at epithelial surfaces such as the skin. Malassezia biofilm formation at the skin surface has not yet been addressed.
Ana Filipa Pedrosa, Carmen Lisboa, Joana Branco, Ana C. Almeida, Claudia Mendes, Christian Pellevoisin, Adelino Leite‐Moreira, Isabel M. Miranda, Acacio G. Rodrigues   +8 more
openaire   +2 more sources