Results 231 to 240 of about 9,223,247 (288)

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

Small, EarlyView.
Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale, Andrea Mussini, Òscar Gulías, Montserrat Agut, Melissa Berni, Stefano Pongolini, Stefano Bruno, Alessandro Casnati, Santi Nonell, Cristiano Viappiani, Stefania Abbruzzetti   +10 more
wiley   +1 more source

Skin-on-a-Chip for Cosmetic Safety Assessment: From Reconstructed Skin Models to Regulatory Translation. [PDF]

ACS Omega
Zhu Q, Liu W, Lv X, Wu X.
europepmc   +1 more source

Deciphering Molecular Charge Anisotropy: The Case of Antibody Solutions

Small, EarlyView.
Molecular charge anisotropy emerges as a key determinant of antibody solution behavior. A multiscale framework combining electrostatic mapping, coarse‐grained simulations, and machine‐learning‐assisted optimization identifies charge patterns that reproduce experimental structure factors and predict collective properties across concentration, revealing ...
Fabrizio Camerin, Susana Marín‐Aguilar, Anna Stradner, Peter Schurtenberger, Emanuela Zaccarelli   +4 more
wiley   +1 more source

Optimization of a 3D Skin Equivalent Incorporating Melanocytes or Melanoma Cells for In Vitro Melanoma Research. [PDF]

Bioengineering (Basel)
Hasterok S, Jankovskaja S, Prgomet Z, Ohlsson L, Gustafsson A.   +4 more
europepmc   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Pharmacokinetic Relevance of In Vitro Skin Models: Absorption, Cutaneous Distribution, Metabolism, and Clearance-like Removal in Dermal and Transdermal Drug Testing. [PDF]

Pharmaceutics
Dugonik F, Jeršič U, Kač L, Maver U, Maver T.   +4 more
europepmc   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

Smart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang, Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai   +11 more
wiley   +1 more source

An integrated design strategy for structurally stable full-thickness human skin models with regulatory-qualified barrier assessment. [PDF]

Mater Today Bio
Won J, Son YH, Kim HJ, Kim JA, Jung H, Park YI, Chung S, Park SJ.   +7 more
europepmc   +1 more source

Advances in deep‐tissue fluorescence imaging through optical clearing: A review

VIEW, EarlyView.
Optical clearing refers to techniques that are used to improve the optical transparency of biological tissues. Optical clearing enables imaging of deeper lying tissues as well as 3D volumetric imaging of whole organs. This review examines reports on the integration of optical clearing with advanced fluorescence imaging techniques, with particular ...
Alaka Pramod, Sanoop Pavithran M, Valery V. Tuchin, Santhosh Chidangil, C. S. Suchand Sandeep   +4 more
wiley   +1 more source

Fine-mapping of microbeam radiation therapy-induced DNA damage in 2D cell and 3D epidermis models. [PDF]

Radiat Oncol
Nguyen M, Dombrowsky AC, Treibel F, Müller J, Raulefs S, Bartzsch S, Combs SE, Eder S, Schmid TE, Scherthan H.   +9 more
europepmc   +1 more source