Results 101 to 110 of about 7,722,550 (348)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

An overview of chemical enhanced oil recovery: recent advances and prospects

open access: yesInternational Nano Letters, 2019
Despite the progress made on renewable energy, oil and gas remains the world’s primary energy source. Meanwhile, large amounts of oil deposits remain unrecovered after application of traditional oil recovery methods.
Afeez O. Gbadamosi   +4 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

PROTOCOL: Mutual Help Organizations to Support Recovery Among Individuals Who Use Drugs: A Systematic Review Protocol

open access: yesCampbell Systematic Reviews
This is the protocol for a Campbell systematic review. The objectives are as follows: (1) What kinds of mutual‐help organizations for drug use disorders have been studied with evidence available in the empirical literature?
Emily A. Hennessy   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The ‘Paths to everyday life’ (PEER) trial – a qualitative study of mechanisms of change from the perspectives of individuals with mental health difficulties participating in peer support groups led by volunteer peers

open access: yesBMC Psychiatry
Background Worldwide, peers support has been shown to play a crucial role in supporting people with mental illness in their personal recovery process and return to everyday life.
Cecilie Høgh Egmose   +3 more
doaj   +1 more source

Biodiversity recovery of Neotropical secondary forests

open access: yesScience Advances, 2019
Tropical secondary forests recover quickly (decades) in tree species richness but slowly (centuries) in species composition. Old-growth tropical forests harbor an immense diversity of tree species but are rapidly being cleared, while secondary forests ...
D. Rozendaal   +85 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

New Solvent for Polyamide 66 and Its Use for Preparing a Single-Polymer Composite-Coated Fabric

open access: yesInternational Journal of Polymer Science, 2018
Polyamides (PAs) are one of the most important engineering polymers; however, the difficulty in dissolving them hinders their applications. Formic acid (FA) is the most common solvent for PAs, but it has industrial limitations.
Mostafa Jabbari   +3 more
doaj   +1 more source

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