Results 71 to 80 of about 458,570 (289)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Recruitment, selection and adaptation of the employees in Chotěbořské strojírny služby, a.s. company [PDF]

open access: yes, 2008
The thesis is focused on recruitment, selection and adaptation of employees in Chotěbořské strojírny služby, a.s. company. At first I defined theoretical principles and methodology and then I characterized company that I have chosen.
Slanařová, Michala
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Effective recruitment selection and adaptation of sales representatives [PDF]

open access: yes, 2009
This bachelor thesis has been focused on sales representatives recruitment selection and their following adaptation. There are clear determined and linked activities which precede recruitment and adaptation process.
Kahounová, Lucie
core  

Ineffective Recruitment & Selection Process Could Lead to an Inefficient Workforce – A Case Study on BEXIMCO Pharmaceuticals Ltd. (BPL) [PDF]

open access: yes, 2023
BPL was established by the BEXIMCO Group in 1976 with the goal to provide the best medicine at an affordable price in Bangladesh. Today, it is leading the pharmaceutical industry in this country.
Nawar, Wamia
core  

Improvement Strategy of Employee Performance PT. Perkebunan Nusantara V

open access: yesMedia Ekonomi dan Manajemen, 2019
PT. Perkebunan Nusantara V is one of the companies engaged in oil palm plantations. During the 2011-2017 period PTPN V carried out the recruitment and selection process with a span of 2 years.
Hendrasyah Putra, Syamsul Maarif
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recruitment, Selection and Adaptation of Employees to Trainee Programmes [PDF]

open access: yes
The aim of the thesis is to analyse the course and identify the characteristics of the personnel processes of recruitment, selection, and adaptation of employees to trainee programmes.
Moudrá, Michaela
core   +3 more sources

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