Results 11 to 20 of about 5,235,363 (361)

A rectal cancer organoid platform to study individual responses to chemoradiation

Nature Medicine, 2019
Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental research questions relevant to patients.
K. Ganesh, Chao Wu, K. O’Rourke, K. O’Rourke, Bryan C Szeglin, Bryan C Szeglin, Youyun Zheng, C. Sauvé, M. Adileh, I. Wasserman, Michael R. Marco, Amanda S. Kim, M. Shady, F. Sánchez-Vega, W. Karthaus, H. Won, Seo-Hyun Choi, Raphael A. Pelossof, A. Barlas, Peter Ntiamoah, E. Pappou, Arthur E. Elghouayel, James S. Strong, Ching-Tung Chen, Jennifer W Harris, M. Weiser, G. Nash, J. Guillem, I. Wei, R. Kolesnick, H. Veeraraghavan, Eduardo Ortiz, I. Petkovska, A. Cercek, K. Manova-Todorova, L. Saltz, J. Lavery, R. DeMatteo, J. Massagué, P. Paty, R. Yaeger, Xi Chen, S. Patil, H. Clevers, M. Berger, S. Lowe, J. Shia, P. Romesser, L. Dow, J. García-Aguilar, C. Sawyers, J. Smith   +51 more
semanticscholar   +2 more sources

Diagnostic Value of Plasma Long Non-coding SLC26A4 Antisense RNA 1 Combined with Magnetic Resonance Imaging in Rectal Cancer

The Turkish Journal of Gastroenterology
Background/Aims: The prevalence of rectal cancer is increasing every year due to changes in living and eating habits. Early diagnosis contributes to the treatment and survival of patients.
Zhiqian Li, Mei Pu, Peng Zhou, Tao Zhang, Yang Xu, Yusui Zhang   +5 more
doaj   +2 more sources

The multidisciplinary management of rectal cancer

Nature Reviews Gastroenterology and Hepatology, 2020
Deborah S Keller, Mariana Berho, Rodrigo Oliva Perez   +2 more
exaly   +2 more sources

Use of a Powered Circular Stapler Can Prevent Anastomotic Air Leakage in Robotic Low Anterior Resection for Rectal Cancer

Journal of the Anus, Rectum and Colon, 2023
Objectives: Preventing anastomotic complications during rectal cancer surgery is important. Compared with a manual circular stapler, a powered circular stapler is expected to reduce undesirable tension during anastomosis.
Kenji Nanishi, Hitoshi Hino, Akio Shiomi, Hiroyasu Kagawa, Shoichi Manabe, Yusuke Yamaoka, Kai Chen, Chikara Maeda   +7 more
doaj   +1 more source

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

New England Journal of Medicine, 2022
BACKGROUND Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is caused by a deficiency in mismatch repair.
A. Cercek, M. Lumish, Jenna Sinopoli, Jill A. Weiss, J. Shia, M. Lamendola-Essel, I. El Dika, N. Segal, M. Shcherba, R. Sugarman, Z. Stadler, R. Yaeger, J. Smith, B. Rousseau, G. Argilés, Miteshkumar Patel, A. Desai, L. Saltz, M. Widmar, K. Iyer, Janie Y Zhang, Nicole Gianino, C. Crane, P. Romesser, E. Pappou, P. Paty, J. García-Aguilar, M. Gonen, M. Gollub, M. Weiser, K. Schalper, L. Diaz   +31 more
semanticscholar   +1 more source

Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR)

Journal of Clinical Oncology, 2022
PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.
Jing Jin, Yuan Tang, Chen Hu, Liming Jiang, Jun Jiang, Ning Li, Wenyang Liu, Siyu Chen, Shuai Li, N. Lu, Yong Cai, Yongheng Li, Yuan Zhu, Guang-Hui Cheng, Hong-Yan Zhang, Xin Wang, Su-Yu Zhu, Jun Wang, Gao-Feng Li, Jialin Yang, Kuan Zhang, Y. Chi, Lin Yang, Hai-Tao Zhou, Ai-ping Zhou, S. Zou, H. Fang, Shulian Wang, Hai-zeng Zhang, Xi-shan Wang, Lichun Wei, Wenling Wang, Shi-xin Liu, Yuan-hong Gao, Ye‐Xiong Li   +34 more
semanticscholar   +1 more source

Comparison between robotic‐assisted and laparoscopic sphincter‐preserving operations for ultra‐low rectal cancer

Annals of Gastroenterological Surgery, 2022
Aim Sphincter‐preserving operations for ultra‐low rectal cancer include low anterior and intersphincteric resection. In low anterior resection, the distal rectum is divided by a transabdominal approach, which is technically demanding. In intersphincteric
Tadahiro Kojima, Hitoshi Hino, Akio Shiomi, Hiroyasu Kagawa, Yusuke Yamaoka, Shoichi Manabe, Shunichiro Kato, Marie Hanaoka   +7 more
doaj   +1 more source

Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2022
This selection from the NCCN Guidelines for Rectal Cancer focuses on management of malignant polyps and resectable nonmetastatic rectal cancer because important updates have been made to these guidelines.
A. Benson, A. Venook, M. Al-Hawary, Nilofer Azad, Yi-Jen Chen, K. Ciombor, S. Cohen, H. Cooper, D. Deming, I. Garrido-Laguna, J. Grem, A. Gunn, J. Hecht, Sarah Hoffe, J. Hubbard, S. Hunt, William Jeck, K. Johung, Natalie N. Kirilcuk, S. Krishnamurthi, J. Maratt, W. Messersmith, J. Meyerhardt, E. Miller, M. Mulcahy, Steven J. Nurkin, M. Overman, A. Parikh, Hitendra R. H. Patel, K. Pedersen, L. Saltz, C. Schneider, D. Shibata, J. Skibber, C. Sofocleous, E. Stotsky-Himelfarb, A. Tavakkoli, C. Willett, K. Gregory, Lisa A. Gurski   +39 more
semanticscholar   +1 more source

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.

Cancer Cell, 2022
Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal cancer patients we find that inflammatory cancer-associated fibroblasts (iCAFs) are associated ...
Adele M. Nicolas, M. Pesic, Esther Engel, Paul K Ziegler, M. Diefenhardt, Kilian B. Kennel, F. Buettner, Claire Conche, V. Petrocelli, Eiman Elwakeel, A. Weigert, A. Zinoveva, Maximilian Fleischmann, B. Häupl, Cem Karakütük, H. Bohnenberger, M. H. Mosa, L. Kaderali, J. Gaedcke, M. Ghadimi, F. Rödel, M. C. Arkan, T. Oellerich, C. Rödel, E. Fokas, F. Greten   +25 more
semanticscholar   +1 more source

The Effectiveness of Machine Learning in Predicting Lateral Lymph Node Metastasis From Lower Rectal Cancer: A Single Center Development and Validation Study

Annals of Gastroenterological Surgery, 2022
Aim Accurate preoperative diagnosis of lateral lymph node metastasis (LLNM) from lower rectal cancer is important to identify patients who require lateral lymph node dissection (LLND).
Shunsuke Kasai, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Yusuke Yamaoka, Kai Chen, Kenji Nanishi, Yusuke Kinugasa   +8 more
doaj   +1 more source