Results 21 to 30 of about 143,020 (265)

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Cancer Medicine, 2019
Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs.
Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi   +11 more
doaj   +1 more source

MicroRNA in rectal cancer

World Journal of Gastrointestinal Oncology, 2016
In rectal cancer, one of the most common cancers worldwide, the proper staging of the disease determines the subsequent therapy. For those with locally advanced rectal cancer, a neoadjuvant chemoradiotherapy (CRT) is recommended before any surgery.
Azizian, Azadeh, Gruber, Jens, Ghadimi, B Michael, Gaedcke, Jochen   +3 more
openaire   +3 more sources

Differences in survival between colon and rectal cancer from SEER data. [PDF]

PLoS ONE, 2013
BACKGROUND: Little is known about colorectal cancer or colon and rectal cancer. Are they the same disease or different diseases? OBJECTIVES: The aim of this epidemiology study was to compare the features of colon and rectal cancer by using recent ...
Yen-Chien Lee, Yen-Lin Lee, Jen-Pin Chuang, Jenq-Chang Lee   +3 more
doaj   +1 more source

Rectal metastasis of gastric cancer: a case report

Journal of International Medical Research, 2023
The most common metastatic sites of gastric cancer include the liver, peritoneum, lung, and bone. However, there is a lack of relevant clinical reports regarding rectal metastasis.
Lu Tang, Huifen Li, Jing Lv, Cantu Fang, Huatang Zhang, Jincheng Meng   +5 more
doaj   +1 more source

IGRT in rectal cancer [PDF]

Acta Oncologica, 2008
To date, no great interest has been shown in the clinical implementation of recent Image-guided radiation therapy (IGRT) modalities in rectal cancer since only a few studies have been published on this issue. This may be explained by the fact that with current treatment modalities locoregional recurrences are already very low (around 10%).
Edy, Ippolito, Ine, Mertens, Karin, Haustermans, Maria Antonietta, Gambacorta, Danilo, Pasini, Vincenzo, Valentini   +5 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer [PDF]

Zhongguo aizheng zazhi
Background and purpose: Tumor microangiogenesis is an important basis for tumor growth and metastasis, and its characteristics include angiogenesis, increased vascular permeability and abnormal capillary structure.
SONG Dan, CHAI Yaxin, GE Yanping
doaj   +3 more sources

Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

BMC Cancer, 2018
Background Resistance to preoperative radiotherapy is a major clinical problem in the treatment for locally advanced rectal cancer. The role of NDRG1 in resistance to ionizing radiation in rectal cancer has not been fully elucidated.
Soon-Chan Kim, Young-Kyoung Shin, Ye-Ah Kim, Sang-Geun Jang, Ja-Lok Ku   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source