Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Feasibility of Oral Prenatal Probiotics against Maternal Group B \u3cem\u3eStreptococcus\u3c/em\u3e Vaginal and Rectal Colonization [PDF]
, 2014 Objective To examine the effect of an oral prenatal probiotic on group B Streptococcus (GBS) colonization and to demonstrate the feasibility of a larger randomized controlled trial. Design This pilot study was an open‐label, two‐group quasi‐experiment.
Duster, Megan +4 more
core +1 more source
Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer [PDF]
, 2013 Background : Preoperative radiotherapy (RT) decreases local recurrence rate and improves survival in stage II and III rectal cancer patients. The combination of chemotherapy with RT has a sound radiobiological rationale, and phase II trials of combined ...
Ceelen, Wim +2 more
core +1 more source
Optimization of Ensemble Supervised Learning Algorithms for Increased Sensitivity, Specificity, and AUC of Population-Based Colorectal Cancer Screenings [PDF]
arXiv, 2017 Over 150,000 new people in the United States are diagnosed with colorectal cancer each year. Nearly a third die from it (American Cancer Society). The only approved noninvasive diagnosis tools currently involve fecal blood count tests (FOBTs) or stool DNA tests.
arxiv
Automatic Segmentation of the Prostate on 3D Trans-rectal Ultrasound Images using Statistical Shape Models and Convolutional Neural Networks [PDF]
arXiv, 2021 In this work we propose to segment the prostate on a challenging dataset of trans-rectal ultrasound (TRUS) images using convolutional neural networks (CNNs) and statistical shape models (SSMs). TRUS is commonly used for a number of image-guided interventions on the prostate.
arxiv
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Recent advances in minimally invasive colorectal cancer surgery [PDF]
, 2002 Laparoscopy has improved surgical treatment of various diseases due to its limited surgical trauma and has developed as an interesting therapeutic alternative for the resection of colorectal cancer.
Angele, M. K. +4 more
core +1 more source
Primary posterior perineal herniation of urinary bladder
Journal of Minimal Access Surgery, 2013 Primary perineal hernia is a rare clinical condition wherein herniation of viscera occurs through pelvic diaphragm. They are usually mistaken for sciatic hernia, rectal prolapse or other diseases in the perineum.
Kurumboor Prakash, Palanisami N Kamalesh
doaj +1 more source
Pieces-of-parts for supervoxel segmentation with global context: Application to DCE-MRI tumour delineation [PDF]
, 2016 Rectal tumour segmentation in dynamic contrast-enhanced MRI (DCE-MRI) is a challenging task, and an automated and consistent method would be highly desirable to improve the modelling and prediction of patient outcomes from tissue contrast enhancement characteristics - particularly in routine clinical practice.
arxiv +1 more source