Results 121 to 130 of about 347,214 (307)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Predicted gains from recurrent selection in the BS11 maize population
, 1999 Random genetic drift and inbreeding depression resulting from the use of small effective population size limit the gain of recurrent selection programs.
Guzman, P. S., Lamkey, Kendall
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Genetic gains in popcorn by full-sib recurrent selection [PDF]
Crop Breeding and Applied Biotechnology, 2009 The purpose of this study was to investigate the genetic progress in the fourth selection cycle of full-sibpopcorn families. Two hundred families were evaluated for six agronomic traits, including grain yield (GY) and poppingexpansion (PE), in a random ...
Antonio Teixeira do Amaral Júnior +3 more
doaj
Heterosis and Responses to Selection in Orange-Fleshed Sweetpotato (Ipomoea batatas L.) Improved Using Reciprocal Recurrent Selection. [PDF]
Front Plant Sci, 2022 Grüneberg WJ +6 more
europepmc +1 more source
Hue selectivity from recurrent circuitry in Drosophila
Nature NeuroscienceAbstractIn the perception of color, wavelengths of light reflected off objects are transformed into the derived quantities of brightness, saturation and hue. Neurons responding selectively to hue have been reported in primate cortex, but it is unknown how their narrow tuning in color space is produced by upstream circuit mechanisms.
Matthias P. Christenson +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Recurrent selection as breeding strategy for heat tolerance in wheat
, 2010 The development of heat-tolerant varieties is an important goal of wheat breeding programs, requiring efficient selection methods. In the present study the use of recurrent selection was evaluated as a strategy to improve heat stress tolerance in wheat ...
Melo de Oliveira, Davi +5 more
core +1 more source
Evidence of recurrent selection of mutations commonly found in SARS-CoV-2 variants of concern in viruses infecting immunocompromised patients. [PDF]
Front Microbiol, 2022 Goes LR +7 more
europepmc +1 more source