Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia. [PDF]
Clin Hemorheol Microcirc, 2016 Red blood cell (RBC) deformability is severely decreased in patients with sickle cell anemia (SCA), which plays a role in the pathophysiology of the disease.
Renoux C +13 more
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Monitoring micro-rheological and multi-organ microcirculatory changes in abdominal sepsis in rats – a new approach to analyzing microcirculatory videos [PDF]
Frontiers in PhysiologyBackgroundThe hemorheological and microcirculatory aspects of the pathophysiology of sepsis are partially understood and are often controversial in terms of the dynamics, extent, and correlation of parameters.
Adam Varga +7 more
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Effects of nitric oxide and its congeners on sickle red blood cell deformability. [PDF]
Transfusion, 2015 Sickle cell disease (SCD) is characterized by hemoglobin polymerization upon deoxygenation. Polymerization causes the sickle cells to become rigid and misshapen (sickling). Red blood cell (RBC) dehydration greatly increases polymerization.
Belanger AM +4 more
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Editorial: Red Blood Cell Vascular Adhesion and Deformability [PDF]
Frontiers in Physiology, 2020 Helene Guizouarn, Gregory Barshtein
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To deform or not to deform: the evolutionary basis of mammalian red blood cell deformability. [PDF]
Biophys J, 2021 Tutwiler V.
europepmc +3 more sources
Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion.
Blood, 2017 Carden MA +10 more
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iScience, 2023 Summary: Several hematologic diseases, including malaria, diabetes, and sickle cell anemia, result in a reduced red blood cell deformability. This deformability can be measured using a microfluidic device with channels of varying width.
Daniel T. Rademaker +9 more
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Nitric oxide, 2022 The rheological properties of red blood cells (RBCs) play an important role in their microcirculation. RBCs can elastically deform in response to mechanical forces to pass through narrow vessels for effective gas exchange in peripheral tissues. Decreased
Jun Kobayashi +3 more
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Reversibility of red blood cell deformation [PDF]
Physical Review E, 2012 The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton.
Zeitz, Maria, Sens, P.
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Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis
Metabolites, 2021 Many factors in the surrounding environment have been reported to influence erythrocyte deformability. It is likely that some influences represent reversible changes in erythrocyte rigidity that may be involved in physiological regulation, while others ...
Jean-Frédéric Brun +4 more
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