Results 101 to 110 of about 970,952 (293)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Prevalence of Non-responders for Glucose Control Markers after 10 Weeks of High-Intensity Interval Training in Adult Women with Higher and Lower Insulin Resistance

Frontiers in Physiology, 2017
Background: Exercise training improves performance and biochemical parameters on average, but wide interindividual variability exists, with individuals classified as responders (R) or non-responders (NRs), especially between populations with higher or ...
Cristian Álvarez, Cristian Álvarez, Rodrigo Ramírez-Campillo, Rodrigo Ramírez-Campillo, Robinson Ramírez-Vélez, Mikel Izquierdo   +5 more
doaj   +1 more source

Forbidden oxygen lines at various nucleocentric distances in comets

, 2014
To study the formation of the [OI] lines - i.e., 5577 A (the green line), 6300 A and 6364 A (the two red lines) - in the coma of comets and to determine the parent species of the oxygen atoms using the green to red-doublet emission intensity ratio (G/R ...
Bhardwaj, A., Decock, A., Hubert, B., Hutsemékers, D., Jehin, E., Manfroid, J., Raghuram, S., Rousselot, P.   +7 more
core   +3 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy — A stereological study

Neurobiology of Disease, 2015
Total numbers of neurons, oligodendrocytes, astrocytes, and microglia in the basal ganglia and red nucleus were estimated in brains from 11 patients with multiple system atrophy (MSA) and 11 age- and gender-matched control subjects with unbiased ...
Lisette Salvesen, Birgitte H. Ullerup, Fatma B. Sunay, Tomasz Brudek, Annemette Løkkegaard, Tina K. Agander, Kristian Winge, Bente Pakkenberg   +7 more
doaj   +1 more source

Activity of comet 103P/Hartley 2 at the time of the EPOXI mission fly-by

, 2012
Comet 103P/Hartley~2 was observed on Nov. 1-6, 2010, coinciding with the fly-by of the space probe EPOXI. The goal was to connect the large scale phenomena observed from the ground, with those at small scale observed from the spacecraft. The comet showed
A’Hearn, A’Hearn, Beer, Carusi, Cesarsky, Elena Mazzotta Epifani, Epifani, Farnham, Gian Paolo Tozzi, Hainaut, Harmon, Hermann Boehnhardt, Javier Licandro, John Robert Brucato, Karen Meech, Licandro, Lisse, Lowry, Lowry, Luisa Lara, Marco Del Bó, Mazzotta Epifani, Meech, Olivier R. Hainaut, Paolo Tanga, Patrizio Patriarchi, Samarasinha, Snodgrass, Snodgrass, Tozzi   +29 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Spatial variations and precise location of substantia nigra hyperechogenicity in Parkinson’s disease using TCS-MR fusion imaging

npj Parkinson's Disease
Substantia nigra hyperechogenicity (SNH) assessed by transcranial sonography (TCS) is a neuroimaging biomarker of Parkinson’s disease (PD), but its actual location and spatial changes are poorly understood.
Chao Hou, Wei Zhang, Hong-Bing Li, Shuo Li, Fang Nie, Xue-Mei Wang, Wen He   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source