Results 81 to 90 of about 970,952 (293)

Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction [PDF]

, 2018
The brain communicates with the spinal cord through numerous axon tracts that arise from discrete nuclei, transmit distinct functions, and often collateralize to facilitate the coordination of descending commands.
Blackmore, Murray G., Maunze, Brian, Tsoulfas, Pantelis, Wang, Yunfang, Wang, Zimei   +4 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Neurobiology of Disease, 2009
The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as extraneuronal plaques.
Cassia R. Overk, Christy M. Kelley, Elliott J. Mufson   +2 more
doaj   +1 more source

Tev Observations of the Variability and Spectrum of Markarian 421 [PDF]

, 1997
Markarian 421 was the first extragalactic source to be detected with high statistical certainty at TeV energies. The Whipple Observatory gamma-ray telescope has been used to observe the Active Galactic Nucleus, Markarian 421 in 1996 and 1997.
Bond, I. H., Boyle, P. J., Bradbury, S. M., Breslin, A. C., Buckley, J. H., Burdett, A. M., Bussons~Gordo, J., Carter-Lewis, D. A., Catanese, M., Cawley, M. F., Fegan, D. J ., Finley, J. P., Gaidos, J., Hall, A., Hillas, A. M., Krennrich, F., Lamb, R. C., Lessard, R. W., Masterson, C., McEnery, J. E., Mohanty, G., Moriarty, P., Quinn, J., Rodgers, A. J., Rose, H. J ., Samuelson, F. W., Sembroski, G. H., Srinivasan, R., Weekes, T. C., Zweerink, J.   +29 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Interactions among intermediate redshift galaxies. The case of SDSSJ134420.86+663717.8

, 2020
We present the properties of the central supermassive black holes and the host galaxies of the interacting object SDSSJ134420.86+663717.8. We obtained optical long slit spectroscopy data from the Large Binocular Telescope (LBT) using the Multi Object ...
Bowles, Micah, Busch, Gerold, Eckart, Andreas, Fazeli, Nastaran, Misquitta, Persis, Valencia-S., Monica, Yttergren, Madeleine   +6 more
core   +1 more source

The rotation and coma profiles of comet C/2004 Q2 (Machholz) [PDF]

, 2007
Aims. Rotation periods of cometary nuclei are scarce, though important when studying the nature and origin of these objects. Our aim is to derive a rotation period for the nucleus of comet C/2004 Q2 (Machholz). Methods. C/2004 Q2 (Machholz) was monitored
Augusteijn, Bertin, Bonev, C. Waelkens, Cochran, Combi, Cousins, Crifo, D. Bodewits, Degroote, Delsemme, Eddington, Farnham, Farnham, Fulle, Haser, Ip, J. Cuypers, Jewitt, Jewitt, Jewitt, Jewitt, Jones, Jorda, Jurkevich, Kawakita, Lara, Licandro, Lin, Lomb, M. Reyniers, Machholz, Meech, Meech, O'Mahony, P. Degroote, Rufener, Samarasinha, Sastri, Scargle, Schleicher, Schulz, Schulz, Stellingwerf, Thuan, Wallace   +45 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Imaging Features of Hypertrophic Olivary Degeneration

Journal of the Belgian Society of Radiology, 2016
Hypertrophic olivary degeneration (HOD) is a unique form of transneuronal degeneration caused by a disruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain-Mollaret.
Ruth Van Eetvelde, M Lemmerling, T Backaert, N Favoreel, B Geerts, C Sommeling, D Hemelsoet, S Dekeyzer   +7 more
doaj   +1 more source

Highly extinguished emission line outflows in the young radio source PKS 1345+12 [PDF]

, 2003
(Abridged) We present new, intermediate resolution spectra (~4A) of the compact radio source PKS 1345+12. Our spectra clearly show extended line emission (~20kpc) consistent with the asymmetric halo of diffuse emission observed in optical and infra-red ...
Holt, J., Morganti, R., Tadhunter, C. N.
core   +2 more sources