Results 91 to 100 of about 970,952 (293)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Keplerian orbit of G2

, 2013
We give an update of the observations and analysis of G2 - the gaseous red emission-line object that is on a very eccentric orbit around the Galaxy's central black hole and predicted to come within 2400 Rs in early 2014. During 2013, the laser guide star
Becklin, E., Boehle, A., Do, T., Ghez, A. M., Lu, J. R., Meyer, L., Morris, M. R., Phifer, K., Sitarski, B. N., Witzel, G., Yelda, S.   +10 more
core   +1 more source

A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis [PDF]

, 2017
In development and disease, cells move as they exchange signals. One example is found in vertebrate development, during which the timing of segment formation is set by a ‘segmentation clock’, in which oscillating gene expression is synchronized across a ...
Bhavna, Rajasekaran, Morelli, Luis Guillermo, Oates, Andrew C., Uriu, Koichiro   +3 more
core   +4 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Brain monoamine systems in multiple system atrophy: A positron emission tomography study

Neurobiology of Disease, 2012
Post-mortem studies of multiple system atrophy (MSA) patients have shown widespread subcortical neurodegeneration. In this study, we have used 18F-dopa PET, a marker of monoaminergic nerve terminal function, to explore in vivo changes in striatal and ...
Stephanie J. Lewis, Nicola Pavese, Maria Rivero-Bosch, Karla Eggert, Wolfgang Oertel, Christopher J. Mathias, David J. Brooks, Alex Gerhard   +7 more
doaj   +1 more source

Hubble Space Telescope Pixel Analysis of the Interacting Face-on Spiral Galaxy NGC 5194 (M51A)

, 2011
A pixel analysis is carried out on the interacting face-on spiral galaxy NGC 5194 (M51A), using the HST/ACS images in the F435W, F555W and F814W (BVI) bands.
Chang Hee Ree, Charlot, Conti, de Vaucouleurs, Durrell, Feldmeier, Granato, Granato, Hong Soo Park, Hwang, Hwang, Hwang, Jaemann Kyeong, Jiwon Chung, Joon Hyeop Lee, Kaleida, Kassin, La Barbera, Lamers, Lee, Lee, Lee, Lee, Lindblad, Matsushita, Meidt, Mutchler, Sandage, Sang Chul Kim, Schlegel, Terashima, Welikala, Welikala   +32 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Light-induced degradation of phyA is promoted by transfer of the photoreceptor into the nucleus [PDF]

, 2018
Higher plants possess multiple members of the phytochrome family of red, far-red light sensors to modulate plant growth and development according to competition from neighbors. The phytochrome family is composed of the light-labile phyA and several light-
Debrieux, Dimitry, Fankhauser, Christian
core  

Multiple Stellar Populations in the Globular Cluster omega Centauri as Tracers of a Merger Event

, 1999
The discovery of the Sagittarius dwarf galaxy, which is being tidally disrupted by and merging with the Milky Way, supports the view that the halo of the Galaxy has been built up at least partially by the accretion of similar dwarf systems.
A Sarajedini, A. R. Walker, AC Layden, H.-c. Lee, J.-M. Joo, JE Norris, L Searle, P Demarque, PB Stetson, RA Ibata, Rvd Woolley, S van den Bergh, S.-C. Rey, Y-W Lee, Y.-J. Sohn, Y.-W. Lee   +15 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source