Results 111 to 120 of about 2,353,407 (330)
Infra-Red Frequency Shifts [PDF]
Nature, 1960 THE effect of liquefaction and solution in different solvents on infra-red group frequencies has previously been considered in terms of changes in dielectric constant and postulated local association effects (for example, Caldow and Thompson1, and Bellamy and Williams2).
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Monthly Notices of the Royal Astronomical Society, 1960 Shortly after Rowland's fundamental study of the wavelengths of Fraunhofer lines, Jewell in 1896 observed that the solar wavelengths were shifted to the red side of the corresponding wavelengths observed in the laboratory. This shift became known as the red shift of solar lines, and at first led to various erroneous concepts of conditions in the solar ...
openaire +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A tentative explanation of cosmological red shift [PDF]
The authors suggest a possible alternative explanation of cosmological red shift. They consider that there exists a background field in the universe, and that light (the photon) has an extremely weak interaction with this background, and as result ...
Chang, T., Torr, D. G.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
An unusual red‐edge excitation and time‐dependent Stokes shift in the single tryptophan mutant protein DD‐carboxypeptidase from Streptomyces: The role of dynamics and tryptophan rotamers [PDF]
, 2007 Giovanni Maglia +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source