Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Experimental Characterization of In Silico Red-Shift-Predicted iLOVL470T/Q489K and iLOVV392K/F410V/A426S Mutants. [PDF]
ACS Omega, 2022 Wehler P +5 more
europepmc +1 more source
Zeno-Gravity Correspondence: Zeno's Dichotomy Paradox and Gravitational red-shift near Event Horizon
, 2016 We relate Zeno's Dichotomy paradox with gravitational red-shift near event horizon in a spherically symmetric space-time. A dictionary of this connection, henceforth called as Zeno-Gravity correspondence, has been built up.
Grinstein, Benjamin, Pal, Sridip
core
Selective Modification for Red‐Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry [PDF]
, 2020 Yvonne Becker +8 more
openalex +1 more source
Experimental characterization ofin silicored-shift predicted iLOVL470T/Q489Kand iLOVV392K/F410V/A426Smutants [PDF]
, 2021 Pierre Wehler +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Red-Shift (2-Hydroxyphenyl)-Benzothiazole Emission by Mimicking the Excited-State Intramolecular Proton Transfer Effect. [PDF]
Front Chem, 2021 Ren Y, Zhou L, Li X.
europepmc +1 more source
Dark Energy Constraints on Red-Shift-Based Gravity [PDF]
, 2013 Setareh Dabbaghchian, Reza Saffari
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source