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Redox regulation of immunometabolism

Nature Reviews Immunology, 2020
Metabolic pathways and redox reactions are at the core of life. In the past decade(s), numerous discoveries have shed light on how metabolic pathways determine the cellular fate and function of lymphoid and myeloid cells, giving rise to an area of research referred to as immunometabolism.
Jonathan Muri, Manfred Kopf
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Redox Regulation of RhoA

Biochemistry, 2006
We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo   +3 more
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Redox regulation: an introduction

Physiologia Plantarum, 2004
The redox‐state is a critical determinate of cell function, and any major imbalances can cause severe damage or death. The cellular redox status therefore needs to be sensed and modulated before such imbalances occur. Various redox‐active components are involved in these processes, including thioredoxins, glutaredoxins and other thiol/disulphide ...
Dietz, Karl-Josef, Scheibe, R
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Redox Circuitries Driving Src Regulation

Antioxidants & Redox Signaling, 2014
Here, we review recent advances with regard to the role of Src kinase in the regulation of cytoskeleton organization, cell adhesion, and motility, focusing on redox circuitries engaging this kinase for anchorage and motility, control of cell survival to anoikis, as well as metabolic deregulation, all features belonging to the new hallmarks of cancer ...
GIANNONI, ELISA, CHIARUGI, PAOLA
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REDOX REGULATION OF CELLULAR ACTIVATION

Annual Review of Immunology, 1997
▪ Abstract  Growing evidence has indicated that cellular reduction/oxidation (redox) status regulates various aspects of cellular function. Oxidative stress can elicit positive responses such as cellular proliferation or activation, as well as negative responses such as growth inhibition or cell death.
H, Nakamura, K, Nakamura, J, Yodoi
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Periplasmic Redox Regulation

Science, 2009
A thioredoxin-like enzyme controls the oxidation state of the bacterial periplasm.
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Redox Regulation of Cellular Signalling

Cellular Signalling, 1999
Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation, through the cellular signalling system. Binding of growth factors to the respective receptor leads to the activation of receptor tyrosine kinases, which in turn stimulate downstream signalling systems such as mitogen-activated protein (MAP) kinases ...
H, Kamata, H, Hirata
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Redox Regulation of Hexokinases

Antioxidants & Redox Signaling, 2019
Hexokinases are key enzymes that are responsible for the first reaction of glycolysis, but they also moonlight other cellular processes, including mitochondrial redox signaling regulation. Modulation of hexokinase activity and spatiotemporal location by reactive oxygen and nitrogen species as well as other gasotransmitters serves as the basis for a ...
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