Results 271 to 280 of about 211,652 (303)

Redox Regulation of Cellular Signalling

Cellular Signalling, 1999
Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation, through the cellular signalling system. Binding of growth factors to the respective receptor leads to the activation of receptor tyrosine kinases, which in turn stimulate downstream signalling systems such as mitogen-activated protein (MAP) kinases ...
H, Kamata, H, Hirata
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Redox Regulation of Hexokinases

Antioxidants & Redox Signaling, 2018
Significance: Hexokinases are key enzymes that are responsible for the first reaction of glycolysis, but they also moonlight other cellular processes, including mitochondrial redox signaling regulation. Modulation of hexokinase activity and spatiotemporal location by reactive oxygen and nitrogen species as well ...
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Redox regulation of development and regeneration

Current Opinion in Genetics & Development, 2019
Oxygen is essential to contemporary life, providing the major electron sink underlying cellular energy metabolism. In addition to providing energy, largely involving redox reactions within mitochondria, oxidative metabolism produces reactive byproducts that are damaging to cellular components.
James A, Coffman, Yi-Hsien, Su
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Redox regulation of TNF signaling

BioFactors, 1999
AbstractTNF is produced during inflammation and induces, among other activities, cell death in sensitive tumour cells. We previously reported an increased generation of ROS in TNF‐treated L929 fibrosarcoma cells prior to cell death. These ROS are of mitochondrial origin and participate in the cell death process.
V, Goossens, K, De Vos, D, Vercammen, M, Steemans, K, Vancompernolle, W, Fiers, P, Vandenabeele, J, Grooten   +7 more
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Redox Regulation of Copper–Metallothionein

Archives of Biochemistry and Biophysics, 1999
Copper (Cu) is an essential element whose localization within cells must be carefully controlled to avoid Cu-dependent redox cycling. Metallothioneins (MTs) are cysteine-rich metal-binding proteins that exert cytoprotective effects during metal exposure and oxidative stress.
J P, Fabisiak, V A, Tyurin, Y Y, Tyurina, G G, Borisenko, A, Korotaeva, B R, Pitt, J S, Lazo, V E, Kagan   +7 more
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Redox Regulation of the Glucocorticoid Receptor

Antioxidants & Redox Signaling, 1999
Redox regulation is currently considered as a mode of signal transduction for coordinated regulation of a variety of cellular processes. The transcriptional regulation of gene expression is also influenced by cellular redox state, most possibly through the oxido-reductive modification of transcription factors.
H, Tanaka, Y, Makino, K, Okamoto, T, Iida, K, Yan, N, Yoshikawa   +5 more
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Redox regulation of intercellular transport

Protoplasma, 2010
Plant cells communicate with each other via plasmodesmata (PDs) in order to orchestrate specific responses to environmental and developmental cues. At the same time, environmental signals regulate this communication by promoting changes in PD structure that modify symplastic permeability and, in extreme cases, isolate damaged cells.
Yoselin, Benitez-Alfonso, David, Jackson, Andy, Maule   +2 more
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Redox-Regulated Mechanisms in Asthma

Antioxidants & Redox Signaling, 2008
Homeostasis of the reduction–oxidation (redox) state is critical to protection from oxidative stress in the lungs. Therefore, the lungs have high levels of antioxidants, including glutathione, heme oxygenase, and superoxide dismutase.
Tomoaki, Hoshino, Masaki, Okamoto, Satoko, Takei, Yuki, Sakazaki, Tomoaki, Iwanaga, Hisamichi, Aizawa   +5 more
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Redox regulation of phosphatase function

Biochemical Society Transactions, 2004
Although reactive oxygen species play important roles in cellular physiology as signalling molecules, their molecular targets are largely unknown. A probable group of targets for mediating many of the effects of reactive oxygen species on cell signalling is the large diverse family of cysteine-dependent phosphatases, which includes the protein tyrosine
N R, Leslie, Y, Lindsay, S H, Ross, C P, Downes   +3 more
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Redox regulation of microRNAs in cancer

Cancer Letters, 2018
Dysregulation of microRNAs (miRNAs) has long been implicated in tumorigenesis, whereas the underlying mechanisms remain largely unknown. Oxidative stress is a hallmark of cancer that involved in multiple pathophysiological processes, including the aberrant regulation of miRNAs.
Jiang, Lan, Zhao, Huang, Junhong, Han, Jichun, Shao, Canhua, Huang   +4 more
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