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Redox regulation of immunometabolism
Nature Reviews Immunology, 2020Metabolic pathways and redox reactions are at the core of life. In the past decade(s), numerous discoveries have shed light on how metabolic pathways determine the cellular fate and function of lymphoid and myeloid cells, giving rise to an area of research referred to as immunometabolism.
Jonathan Muri, Manfred Kopf
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Redox Regulation of the Microcirculation
Comprehensive Physiology, 2020Abstract The microcirculation maintains tissue homeostasis through local regulation of blood flow and oxygen delivery. Perturbations in microvascular function are characteristic of several diseases and may be early indicators of pathological changes in the cardiovascular system and in parenchymal tissue function ...
Andrew O, Kadlec, David D, Gutterman
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Biochemistry, 2006
We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo +3 more
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We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo +3 more
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The Deep Thioredoxome in Chlamydomonas reinhardtii: New Insights into Redox Regulation
Molecular Plant, 2017 Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins.
Maria Esther Perez-Perez +2 more
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Redox‐regulation of DNA repair
BioFactors, 2003Evolution has selected for sophisticated biochemical mechanisms to maintain a reduced environment in all living cells. Not only is this regulation essential for the numerous biological process within the cell to occur, but it is also the protective mechanism which prevents the many endogenous and exogenous biological oxidations in the cell.
Lunec, Joseph +3 more
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Discoveries in the redox regulation of KRAS
The International Journal of Biochemistry & Cell Biology, 2021Oncogenic KRAS is one of the most common drivers of human cancer. Despite intense research, no effective therapy to directly inhibit oncogenic KRAS has yet been approved and KRAS mutant tumors remain associated with a poor prognosis. This short review discusses the current knowledge of the redox regulation of RAS and examines the newest findings on ...
Maximilian, Kramer-Drauberg +1 more
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Redox Regulation of p53, Redox Effectors Regulated by p53: A Subtle Balance
Antioxidants & Redox Signaling, 2012Reactive oxygen species (ROS), generated by cells as side products of biological reactions, function as secondary messengers by impacting a host of cellular networks involved in maintaining normal homeostatic growth as well as pathological disease states.
Maillet, A., Pervaiz, Shazib
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Redox Regulation and Noncoding RNAs
Antioxidants & Redox Signaling, 2018RNA is a heterogeneous class of molecules with the minority being protein coding. Noncoding RNAs (ncRNAs) are involved in translation and epigenetic control mechanisms of gene expression. Recent Advances: In recent years, the number of identified ncRNAs has dramatically increased and it is now clear that ncRNAs provide a complex layer of differential ...
Matthias S, Leisegang +2 more
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Redox regulation of chlorophyll biosynthesis
Phytochemistry, 2010Chlorophyll captures and redirects light-energy and is thus essential for photosynthetic organisms. The demand for chlorophyll differs throughout the day and night and in response to changing light conditions. Moreover, the chlorophyll biosynthesis pathway is up to certain points shared between the different tetrapyrroles; chlorophyll, heme, siroheme ...
Stenbæk, Anne, Jensen, Poul Erik
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Progress in Retinal and Eye Research, 2003
The high content of glutathione (GSH) in the lens is believed to protect thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size. However, ageing lenses or lenses under oxidative stress show an extensively diminished size of GSH pool with ...
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The high content of glutathione (GSH) in the lens is believed to protect thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size. However, ageing lenses or lenses under oxidative stress show an extensively diminished size of GSH pool with ...
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