Results 61 to 70 of about 387,787 (305)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Characterisation of components and mechanisms involved in redox-regulation of protein import into chloroplasts [PDF]

, 2009
The vast majority of chloroplast proteins is encoded in the nucleus and thus has to be posttranslationally imported into the organelle, a process that is facilitated by two multimeric protein machineries, the Toc and Tic complexes (translocon at the ...
Stengel, Anna
core  

Role of glutathionylation in infection and inflammation [PDF]

, 2019
Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell
Baldelli, S., Checconi, P., Ciriolo, M. R., Limongi, D., Nencioni, L., Palamara, A. T.   +5 more
core   +1 more source

Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators

, 2018
Plant stem cells are the foundation of plant growth and development. The balance of quiescence and division is highly regulated, while ensuring that proliferating cells are protected from the adverse effects of environment fluctuations that may damage ...
Abo, Abo, Akter, Akter, Akter, Alcock, Benitez-Alfonso, Brandes, Brennan, Burhans, Charles, Chen, Chen, Chiu, Christine H. Foyer, Considine, Considine, De Schutter, de Simone, Diaz Vivancos, Diaz-Vivancos, Dick, Dinneny, Doka, Dolzblasz, Doulias, Duan, Duan, Edgar, Faccenda, Feher, Foyer, Gomes, Gouge, Gupta, Gupta, Gupta, Halliwell, Hamanaka, Harashima, Held, Horvath, Inze, Jaffrey, Jiang, Kadota, Kanda, Kensler, Kimura, Kuo, Leichert, Liu, Liu, Lo Conte, Lo Conte, Ludin, Magyar, Majmudar, Mangano, Mantel, Marchand, Mayer, Megan H. Wright, Menon, Michael H. Wilson, Mohyeldin, Murray, Narasimha, Nowack, Owusu-Ansah, Parker, Paulech, Paulsen, Peret, Perez-Perez, Pervaiz, Petersen, Poole, Poole, Poole, Potters, Qu, Rauniyar, Reddy, Reichheld, Rosenwasser, Rubin, Salmeen, Samarasinghe, Samarasinghe, Saurin, Scheres, Schieber, Schilling, Schippers, Segui-Simarro, Seneviratne, Singh, Su, Sullivan, Swanson, Takanishi, Takanishi, Tognetti, Topf, Trost, Tsukagoshi, van den Berg, van Geel, Vandepoele, Varum, Velappan, Viola, Wang, Wang, Wang, Waszczak, Webster, Wedmann, Weerapana, Witze, Yadav, Yang, Yang, Yang, Yin, Yu, Zaffagnini, Zeng, Zhang, Zhou, Zhou   +131 more
core   +1 more source

Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression [PDF]

, 2001
Feedback regulation of photosynthesis by carbon metabolites has long been recognized, but the underlying cellular mechanisms that control this process remain unclear.
Dominy, P J, Graham, I A, Martin, T, Oswald, O   +3 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry

Cell Reports, 2020
Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications.
Christine Silvia Gibhardt, Sabrina Cappello, Rajesh Bhardwaj, Romana Schober, Sonja Agnes Kirsch, Zuriñe Bonilla del Rio, Stefan Gahbauer, Anna Bochicchio, Magdalena Sumanska, Christian Ickes, Ioana Stejerean-Todoran, Miso Mitkovski, Dalia Alansary, Xin Zhang, Aram Revazian, Marc Fahrner, Victoria Lunz, Irene Frischauf, Ting Luo, Daria Ezerina, Joris Messens, Vsevolod Vadimovich Belousov, Markus Hoth, Rainer Arnold Böckmann, Matthias Albrecht Hediger, Rainer Schindl, Ivan Bogeski   +26 more
doaj   +1 more source

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]

, 2019
Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin, Loi, Vu Van, Busche, Tobias, Sommer, Anna, Tedin, Karsten, Nürnberg, Dennis J., Kalinowski, Jörn, Bernhardt, Jörg, Fulde, Marcus, Antelmann, Haike   +9 more
core   +1 more source