Results 41 to 50 of about 211,652 (303)
Redox regulation of macrophages
Redox BiologyRedox signaling, a mode of signal transduction that involves the transfer of electrons from a nucleophilic to electrophilic molecule, has emerged as an essential regulator of inflammatory macrophages. Redox reactions are driven by reactive oxygen/nitrogen species (ROS and RNS) and redox-sensitive metabolites such as fumarate and itaconate, which can ...
Nhien Tran, Evanna L. Mills
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Redox Regulation of PTEN by Peroxiredoxins
Antioxidants, 2021 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes.
Thang Nguyen Huu +6 more
doaj +1 more source
Redox regulation of proteasome function
Redox Biology, 2017 Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were ...
Maria Lefaki +2 more
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, 2022 Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behavior in normal and malignant hematopoiesis.
Johansson, E, +10 more
core +1 more source
Redox regulation of chloroplast metabolism [PDF]
, 2021 Regulation of enzyme activity based on thiol-disulfide exchange is a regulatory mechanism in which the protein disulfide reductase activity of thioredoxins (TRXs) plays a central role.
Cejudo Fernández, Francisco Javier +2 more
core +1 more source
Redox regulation of the immune response [PDF]
Redox Report, 2013 Reactive oxygen and nitrogen species (ROS-RNS) and other redox active molecules fulfill key functions in immunity. Beside the initiation of cytocidal reactions within the pathogen defense strategy, redox reactions trigger and shape the immune response and are further involved in termination and initialization of cellular restorative processes ...
Johanna M, Gostner +3 more
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Using the heme peroxidase APEX2 to probe intracellular H2O2 flux and diffusion
Nature CommunicationsCurrently available genetically encoded H2O2 probes report on the thiol redox state of the probe, which means that they reflect the balance between probe thiol oxidation and reduction.
Mohammad Eid +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Redox Regulation of Lymphocyte Signaling [PDF]
IUBMB Life, 2000 AbstractCompelling evidence exists that reactive oxygen species can deliver intracellular signals in mammalian cells, and elicit a broad array of physiological responses according to the cell type, the oxidative burden and the cellular compartment where radicals are generated. When applied to immune cells, these concepts gain a particular relevance, in
G, Pani +3 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source