Results 31 to 40 of about 197,483 (259)
Journal of Pharmacological Sciences, 2006 .: Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack cholecystokinin-A receptor (CCK-AR) because of a genetic abnormality. We observed that body temperature homeostasis in response to changes in ambient temperature was deteriorated in OLETF rats, while
Miyasaka Kyoko +6 more
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Redox regulation of macrophages
Redox BiologyRedox signaling, a mode of signal transduction that involves the transfer of electrons from a nucleophilic to electrophilic molecule, has emerged as an essential regulator of inflammatory macrophages. Redox reactions are driven by reactive oxygen/nitrogen species (ROS and RNS) and redox-sensitive metabolites such as fumarate and itaconate, which can ...
Nhien Tran, Evanna L. Mills
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Redox regulation and the metabolic syndrome [PDF]
Cell Death & Differentiation, 2011 After almost 25 years, it is now the XIth Villa Vigoni conference held at Lago di Como in Northern Italy to focus on redox regulation, this time linked to the metabolic syndrome. Villa Vigoni was again an excellent location for scientific discussions given by 24 speakers (Figure 1).
Maccarrone M, Brüne B
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Using the heme peroxidase APEX2 to probe intracellular H2O2 flux and diffusion
Nature CommunicationsCurrently available genetically encoded H2O2 probes report on the thiol redox state of the probe, which means that they reflect the balance between probe thiol oxidation and reduction.
Mohammad Eid +4 more
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Redox regulation of Nox proteins [PDF]
Respiratory Physiology & Neurobiology, 2010 The generation of reactive oxygen species (ROS) plays a major role in endothelial signaling and function. Of the several potential sources of ROS in the vasculature, the endothelial NADPH oxidase (Nox) family of proteins, Nox1, Nox2, Nox4 and Nox5, are major contributors of ROS. Excess generation of ROS contributes to the development and progression of
Srikanth, Pendyala +1 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Dynamic Redox Regulation of IL-4 Signaling. [PDF]
PLoS Computational Biology, 2015 Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative ...
Gaurav Dwivedi +3 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Redox Biology, 2015 Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis.
Yuliya Mikhed +3 more
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Frontiers in Cellular Neuroscience, 2021 The cellular redox state, or balance between cellular oxidation and reduction reactions, serves as a vital antioxidant defence system that is linked to all important cellular activities.
Cyril Jones Jagaraj +3 more
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